Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
215-535-7
CAS no.:
1330-20-7
Index number:
601-022-00-9
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
26
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a flammable liquid and vapour, is harmful in contact with skin, is harmful if inhaled and causes skin irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may be fatal if swallowed and enters airways, is a highly flammable liquid and vapour, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure, is harmful to aquatic life with long lasting effects and may cause respiratory irritation.

Breakdown of all 7438 C&L notifications submitted to ECHA

Skin Irrit. 2 H315 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Acute Tox. 4 H312 Harmonised Classification
Flam. Liq. 3 H226 Harmonised Classification
Eye Irrit. 2 H319
STOT SE 3 H335
Asp. Tox. 1 H304
STOT RE 2 H373
Aquatic Chronic 3 H412
STOT SE 3 H336
Flam. Liq. 2 H225
Aquatic Chronic 2 H411
Repr. 1B H360
Aquatic Acute 1 H400
STOT SE 1 H370
https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 22 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, anti-freeze products, biocides (e.g. disinfectants, pest control products), polishes and waxes and adhesives and sealants.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: mixing in open batch processes, industrial spraying, transfer of chemicals at dedicated facilities, transfer of substance into small containers, roller or brushing applications, non-industrial spraying and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in complex articles, with no release intended: Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)), machinery, mechanical appliances and electrical/electronic products e.g. refrigerators, washing machines, vacuum cleaners, computers, telephones, drills, saws, smoke detectors, thermostats, radiators, large-scale stationary industrial tools), vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), metal used for large surface area articles (e.g. construction and building materials used for roof sheets, pipes), metal used for packaging (excluding food packaging), metal used for furniture & furnishings (e.g. outdoor furniture, benches, tables), wood used for large surface area articles (e.g. construction and building materials for floors, claddings), wood used for furniture & furnishings and wood.

This substance is used in the following products: fuels, coating products and fillers, putties, plasters, modelling clay.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: coating products, polymers, explosives and plant protection products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, formulation in materials, manufacturing of the substance, in the production of articles and of substances in closed systems with minimal release.

This substance is used in the following products: coating products and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation of mixtures, formulation in materials, in the production of articles and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use non-sparking tools; ground and bond container and receiving equipment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; do not breathe the dust, fume, gas, mist, vapours or spray; use explosion-proof equipment (electrical/ventilating/lighting/etc.); keep container tightly closed; avoid breathing the dust, fume, gas, mist, vapours or spray; take actions to prevent static discharges; use only outdoors or in a well-ventilated area; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If eye irritation persists get medical advice/attention. Take off contaminated clothing and wash it before reuse. Call a poison center or doctor/physician if you feel unwell. Do not induce vomiting. If skin irritation occurs: Get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. Follow specific treatment (see label). If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Baker Hughes (Nederland) B.V, p/a Blokmakersweg 10 1786 RC Den Helder Netherlands
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • DKSH GmbH, Baumwall 3 20459 Hamburg Germany
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • Elementis Minerals B.V., Kajuitweg 8 1041AR Amsterdam Netherlands
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • ICC Industries B.V., Arena Boulevard 61, 4th floor 1101 DL Amsterdam Netherlands
  • ICL Europe Coöperatief U.A., Prinsenhof Building Koningin Wilhelminaplein 30 1062 KR Amsterdam NH Netherlands
  • International Farg AB, Box 44 SE 424 22 Angered Sweden
  • International Paint (Nederland) B.V., Zeemanstraat 79 2991 XR Barendrecht Netherlands
  • NAMA Germany, Röntgenstrasse 12 D-79539 Lörrach Germany
  • PILOT CORPORATION OF EUROPE, PAE de la Caille 74350 ALLONZIER LA CAILLE France
  • Polynt Composite SpA, via Enrico Fermi 51 24020 Scanzorosciate Bergamo Italy
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • YOU Solutions Germany GmbH - REACH (part of Arxada), Freundallee 9 a 30173 Hannover Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Corteva Agriscience Belgium B.V., Rue Montoyer 25, 1000 Brussels Belgium
  • Corteva Agriscience France S.A.S., Immeuble Equinoxe 2 1bis avenue du 8 Mai 1945 78280 Guyancourt France
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Evonik Italia S.r.l., Via Falconera, 7 26025 Pandino (CR) Italy
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • ExxonMobil Chemical Holland B.V., Botlekweg, 121, Haven nr 40-60 NL 3197 KA Botlek Rotterdam Netherlands
  • IVICT Europe GmbH, Kennedydamm 19 40476 Düsseldorf Germany
  • Mentor Medical Systems B.V., Zernikedreef 2 2333 CL Leiden Netherlands
  • NuSil Technology LLC, 1198 Avenue Maurice Donat 06 906 06250 Mougins France
  • OLTCHIM SA, Uzinei 1 240050 Ramnicu Valcea Valcea Romania
  • Petrobras Global Trading B.V., Weena 798C – 23rd floor 3014 DA Rotterdam Netherlands
  • PETROBRAS GLOBAL TRADING BV - PGT BV, Weena 798C – 23rd floor First Rotterdam 3014 DA Rotterdam Netherlands
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • SARPOM S.r.l., Viale Castello della Magliana 25 00148 Roma Italy
  • The Acta Group EU, Ltd (21), Brook House Suite 2B M2 2BQ Manchester United Kingdom
  • Vitol Chemicals BV, K.P. van der Mandelelaan 130 3062 MB Rotterdam Netherlands

Substance names and other identifiers

1,2-xylene; 1,3-xylene; 1,4-xylene
Other
Benzene, dimethyl-
Other
Dimethylbenzene
Other
Ksylen
Other
Methyl toluene
Other
Violet 3
Other
Xiloli
Other
Xylene
EC Inventory, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Xylene
Substance Evaluation - CoRAP, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Xylene, mixed isomers
Occupational Exposure Limits - 1st list - Indicative OELVs
Xylene, mixed isomers, pure
Other
Xylenen
Other
XYLENES
Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
Xylenes (mixed)
Other
Xylol
Other
Xylole
Other
ksilen (hr)
C&L Inventory
ksilen (sl)
C&L Inventory
ksilenas (lt)
C&L Inventory
ksilols (lv)
C&L Inventory
ksyleeni (fi)
C&L Inventory
ksylen dimetylobenzen (pl)
C&L Inventory
Ksüleen (et)
C&L Inventory
xilen (ro)
C&L Inventory
xilene (it)
C&L Inventory
xileno (es)
C&L Inventory
xileno (pt)
C&L Inventory
xilol (izomerek keveréke) (hu)
C&L Inventory
xyleen (nl)
C&L Inventory
xylen (cs)
C&L Inventory
xylen (da)
C&L Inventory
xylen (no)
C&L Inventory
xylen (sv)
C&L Inventory
Xylol (de)
C&L Inventory
xylène (fr)
C&L Inventory
xylén (sk)
C&L Inventory
ξυλόλιο, μίγμα ισομερών (el)
C&L Inventory
ксилен (bg)
C&L Inventory
1,2 dimethylbenzene
C&L Inventory, Registration dossier
1,2-dimethylbenzene
C&L Inventory
1,2-dimethylbenzene, 1,3-dimethylbenzene, 1,4-dimethylbenzene
C&L Inventory
1,2-dimethylbenzene, 1,3-dimethylbenzene, 1,4-dimethylbenzene.
C&L Inventory
1,2-dimethylbenzene: 1,3-dimethylbenzene ; 1,4-dimethylbenzene
C&L Inventory
1,2-dimethylbenzene; 1,3-dimethylbenzene; 1,4-dimethylbenzene
C&L Inventory
1,2-dimethylbenzene; 1,3-xylene; 1,4-xylene
C&L Inventory
1,2-xylene
C&L Inventory
1,2-xylene
C&L Inventory
1,2-xylene; 1,3-xylene; 1,4-xylene
C&L Inventory, Registration dossier
1,2-xylene; 1,3-xylene; 1,4-xylene; dimethylbenzene
Registration dossier
1,3-dimethylbenzene
C&L Inventory
1,3-Xylene
C&L Inventory
Benzene, dimethyl
C&L Inventory
Benzene, dimethyl-
C&L Inventory
Dimethyl Benzene
C&L Inventory
Dimethyl-benzene
C&L Inventory
Dimethylbenzene
C&L Inventory, Registration dossier
Dimethylbenzene
C&L Inventory, Registration dossier
dimethylbenzene, mixture of isomeres
C&L Inventory
Dimethylbenzenes
C&L Inventory
dimethylobenzene
C&L Inventory
dimetilbenzene
C&L Inventory
diméthylbenzène
C&L Inventory
m-xylene
C&L Inventory, Registration dossier
mixture-xylene
C&L Inventory
Not applicable
Registration dossier
Not available
Registration dossier
Reaction mass of 100-41-4 and 106-42-3 and 108-38-3 and 95-47-6
C&L Inventory
Reaction mass of 106-42-3 and 108-38-3 and 95-47-6
C&L Inventory
Reaction mass of [ortho-xylene, meta-xylene, para-xylene & Ethylbenzene]
C&L Inventory
Reaction mass of [ortho-xylene, meta-xylene, para-xylene + Ethylbenzene]
Registration dossier
Reaction mass of butanone and ethylbenzene and toluene and Solvent naphtha (petroleum), heavy arom.
C&L Inventory
Reaction mass of m-xylene and o-xylene and p-xylene and ethylbenzene
Registration dossier
Reaction mass of m-xylene, o-xylene, p-xylene and ethylbenzene
Registration dossier
Reaction mass of o-xylene and ethylbenzene and m-xylene
C&L Inventory
Reaction mass of o-xylene and ethylbenzene and p-xylene and m-xylene
C&L Inventory
Reaction mass of o-xylene and p-xylene and m-xylene
C&L Inventory
Reaction mass of ortho-xylene, meta-xylene, para-xylene & Ethylbenzene
C&L Inventory
Reactionmass of ethylbenzene and xylene isomers
Registration dossier
SHORT OIL ALKYD RESIN
C&L Inventory
Xylen
C&L Inventory
XYLENE
C&L Inventory, Registration dossier
Xylene
C&L Inventory, Registration dossier
xylene (all isomers)
C&L Inventory
xylene (isomers)
C&L Inventory
Xylene (mixed isomers)
C&L Inventory
Xylene (mixture of isomers)
C&L Inventory
xylene (mixture of isomers)
Registration dossier
Xylene isomers
C&L Inventory
xylene mixture of isomers
C&L Inventory
xylene, isomers mixture
C&L Inventory
xylene, mixed isomeres
C&L Inventory
xylene, mixed isomers, pure
C&L Inventory
xylene, mixture of isomers
C&L Inventory
xylenes
C&L Inventory
Xylol
C&L Inventory
Xylol (Isomerengemisch)
C&L Inventory
Xylol-Isomere
C&L Inventory
Xylènes
C&L Inventory
xyxlene
C&L Inventory
Mixed Xylenes
Registration dossier
Not applicable
Registration dossier
POLYFLON PTFE SM-3900
C&L Inventory
Rozcieńczalnik ksylenowy
C&L Inventory
Solvent Xylene
Registration dossier
Tyranno Varnish
C&L Inventory
Xilene
C&L Inventory
Xileno
C&L Inventory
XILENOS
Registration dossier
Xylene
Registration dossier
1330-20-7
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 1st list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
601-022-00-9
Index number
C&L Inventory
8026-09-3
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 18 studies submitted
  • 14 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (93%), Solid (7%) [14]
C Form
Other (100%) [4]
C Substance type
Organic (100%) [12]

Type of Study provided
Studies with data
Key study 5 5 4
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 24 studies submitted
  • 12 studies processed
R Melting / freezing point
-94.96 - 13.25 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 4 4 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-39.3 - -38.67 °C

Boiling point

Study results
  • 24 studies submitted
  • 12 studies processed
R Boiling point
136.16 - 144.5 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 3 4 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
139.49 - 139.6 °C

Density

Study results
  • 24 studies submitted
  • 18 studies processed
R Density
0.86 - 0.88 g/cm³ @ 25 °C [6]
R Relative density
0.86 - 0.88 @ 20 - 25 °C [12]

Type of Study provided
Studies with data
Key study 7 7 4
Supporting study 1 1 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.86 - 0.867

Vapour pressure

Study results
  • 25 studies submitted
  • 12 studies processed
R Vapour pressure
12.824 - 14.272 hPa @ 26.667 - 32.222 °C [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 4 4 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
8.21 - 11.057 hPa @ 20 - 25 °C

Partition coefficient

Study results
  • 34 studies submitted
  • 12 studies processed
R Log Pow
3.12 - 3.2 @ 20 °C and pH 7 [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 6 8 7
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
3.155 - 3.16 @ 20 °C

Water solubility

Study results
  • 25 studies submitted
  • 12 studies processed
R Water solubility (mass/vol.)
146 - 208 mg/L @ 25 °C and pH 7 [18]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 5 4 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
162.375 - 165.8 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4 4
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
28.7 - 28.747 mN/m

Flash point

Study results
  • 25 studies submitted
  • 12 studies processed
R Flash point
18 - 32 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study 4 4 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
18 °C

Auto flammability

Study results
  • 13 studies submitted
  • 12 studies processed
R Autoflammability / self-ignition
432 - 528 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
487.5 - 488 °C

Flammability

Study results
  • 13 studies submitted
  • 12 studies processed
C Interpretation of results
Extremely flammable (100%) [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 12 studies submitted
  • 12 studies processed
R dynamic viscosity (in mPa s)
0.581 - 0.76 [12]

Type of Study provided
Studies with data
Key study 4 4 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
0.74 - 0.743 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 20 studies submitted
  • 19 studies processed
R Dissipation half life (DT50)
18.936 - 51.36 h [21]

Type of Study provided
Studies with data
Key study 1 7 7 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
48 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 51 studies submitted
  • 30 studies processed
R BOD5
1.4 - 2.53 g O2/g test material [9]
R COD
2.56 - 2.91 g O2/g test material [9]
C Interpretation of results
Readily biodegradable (75%), Readily biodegradable but failing the 10-day window (13%), Inherently biodegradable (13%) [24]

Type of Study provided
Studies with data
Key study 6 3
Supporting study
Weight of evidence 9 13 5 12
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in soil
23 days @ 28 °C

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 3 4 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - dimensionless
25.9

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 7 studies submitted
  • 2 studies processed
R Koc
537 dimensionless [2]
R log Koc
2.73 dimensionless [2]

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study 1 1 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
537

Henrys law constant (H)

Study results
  • 23 studies submitted
  • 13 studies processed
R H - (pressure) m³/mol
425 - 900 Pa m³/mol @ 25 °C and 101.3 kPa [45]

Type of Study provided
Studies with data
Key study 4 5 4
Supporting study 4 3 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
623 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 44 - 327 µg/L (2)
Intermittent releases (freshwater) 10 - 327 µg/L (2)
Marine water 4.4 - 327 µg/L (2)
Intermittent releases (marine water) 1 µg/L (1)
Sewage treatment plant (STP) 1.6 - 6.58 mg/L (2)
Sediment (freshwater) 2.52 - 12.46 mg/kg sediment dw (2)
Sediment (marine water) 252 - 12 460 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 852 - 2 310 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 34 studies submitted
  • 19 studies processed
P/RResults
LC50 (4 days) 2.6 - 9.6 mg/L [14]
LL50 (72 h) 4.667 - 5.921 mg/L [7]

Type of Study provided
Studies with data
Key study 4 7 4 4
Supporting study 5 5 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 11 studies submitted
  • 10 studies processed
P/RResults
NOEC (56 days) 1.3 mg/L [2]
NOEC (35 days) 714 µg/L [2]
LOEC (35 days) 1.29 mg/L [2]
NOELR (21 days) 894 - 1 134 µg/L [7]

Type of Study provided
Studies with data
Key study 1 4 4 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 28 studies submitted
  • 19 studies processed
P/RResults
IC50 (24 h) 1 - 4.7 mg/L [12]
LC50 (48 h) 10.389 mg/L [2]
LL50 (48 h) 8.73 - 11.076 mg/L [5]

Type of Study provided
Studies with data
Key study 4 7 4 4
Supporting study 3 3 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 16 studies submitted
  • 16 studies processed
P/RResults
NOEC (21 days) 1.57 mg/L [3]
NOEC (7 days) 960 - 1 170 µg/L [6]
LOEC (21 days) 3.16 mg/L [3]
EC10 (21 days) 1.91 mg/L [3]
NOELR (21 days) 1.672 - 2.122 mg/L [7]

Type of Study provided
Studies with data
Key study 3 6 4 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 37 studies submitted
  • 19 studies processed
P/RResults
EC50 (73 h) 2.2 - 4.36 mg/L [6]
EC50 (72 h) 4.6 - 4.9 mg/L [9]
NOEC (73 h) 440 µg/L [3]
EC10 (73 h) 720 - 1 900 µg/L [6]
EC90 (73 h) 4.4 - 10 mg/L [6]

Type of Study provided
Studies with data
Key study 4 7 4 4
Supporting study 6 6 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
1.3 - 4.36 mg/L
EC10 or NOEC for freshwater algae
440 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 28 studies submitted
  • 9 studies processed
P/RResults
NOEC (28 days) 16 - 16.2 mg/L [9]

Type of Study provided
Studies with data
Key study 6 6 4
Supporting study 4 4 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
71.286 - 96 mg/L
EC10 or NOEC for microorganisms
16 mg/L

Sediment toxicity

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 16 studies submitted
  • 4 studies processed
P/RResults
NOEC (56 days) 42.6 - 93.1 mg/kg soil dw [10]
LOEC (56 days) 71.1 - 152 mg/kg soil dw [10]
EC10 (56 days) 67.5 - 70.8 mg/kg soil dw [4]
LC10 (56 days) 71.4 - 88.8 mg/kg soil dw [4]
EC50 (56 days) 88.8 - 93.2 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 1 5 3 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
88.8 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
16 - 42.6 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 13 studies submitted
  • 7 studies processed
P/RResults
other: (28 days) 2.379 - 41.844 mg/kg soil dw [14]

Type of Study provided
Studies with data
Key study 3 4
Supporting study 2 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 19 studies submitted
  • 3 studies processed
P/RResults
EC25 (14 days) 3 - 462 mg/kg soil dw [12]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 5 6 4
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Short-term EC50 / LC50
1 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC25 (28 days) 1 g/kg soil dw [4]
EC25 (7 days) 669 mg/kg soil dw [2]
EC50 (28 days) 1 g/kg soil dw [4]
EC50 (7 days) 867 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50
220 - 867 mg/kg soil dw

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 221 mg/m³ neurotoxicity
Acute /short term: (DNEL) 442 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 221 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 442 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 212 mg/kg bw/day neurotoxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 65.3 mg/m³ neurotoxicity
Acute /short term: (DNEL) 260 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 65.3 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 260 mg/m³ neurotoxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 125 mg/kg bw/day neurotoxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 10 10 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal absorption
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 3 2 2 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 15 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 8 studies processed
P/RResults
LD50 3 523 - 6 631 mg/kg bw (rat) [8]
LD50 5 251 - 5 627 mg/kg bw (mouse) [6]
M/CInterpretations of results
GHS criteria not met [6]

Type of Study provided
oral
Studies with data
Key study 5 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 30 studies submitted
  • 7 studies processed
P/RResults
LC50 (4 h) 5 922 - 6 700 ppm (rat) [11]
M/CInterpretations of results
GHS criteria not met [5]

inhalation
Studies with data
Key study 6 2
Supporting study 18 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 12 126 mg/kg bw (rabbit) [3]
LD50 5 - 5 000 mL/kg bw (rabbit) [2]
M/CInterpretations of results
GHS criteria not met [3]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 3 523 mg/kg bw
Inhalation route:
Adverse effect observed LC50 27.124 mg/L air
Dermal route:
Adverse effect observed LD50 12 126 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study 5 5
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 3 3
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 34 studies submitted
  • 14 studies processed
P/RResults
NOAEL (rat): 100 - 1 000 mg/kg bw/day [21]
LOAEL (rat): 150 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 9 5
Supporting study 10 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 5
Exposure cons.
Other 2
Study data: inhalation
  • 11 studies submitted
  • 6 studies processed
P/RResults
NOAEC (rat): 450 - 1 800 ppm [12]

Study data: inhalation
Studies with data
Key study 4 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 250 mg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 3 515 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 11 6
Supporting study 12 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: in vivo
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 7 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4 2 1
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: developmental
  • 67 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 16 10 2
Supporting study 20 9
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 5
Exposure cons.
Other 5
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 300 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed BMCL10 4 190 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 25 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 3 2
Supporting study 7 7 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant