Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-659-6
CAS no.:
67-56-1
Index number:
603-001-00-X
Molecular formula:
CH4O
SMILES:
CO
InChI:
InChI=1S/CH4O/c1-2/h2H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
51
Of which contain:
10 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, is toxic if inhaled, causes damage to organs and is a highly flammable liquid and vapour.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of causing cancer.

Breakdown of all 7599 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
STOT SE 1 H370 Harmonised Classification
Acute Tox. 3 H301 Harmonised Classification
STOT SE 2 H371
Eye Irrit. 2 H319
Skin Irrit. 2 H315
STOT RE 1 H372
Repr. 1B H360
Not Classified
Carc. 2 H351
STOT SE 3 H336
Acute Tox. 2 H300
Skin Corr. 1A H314
https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (0.32% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 265 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 000 to < 100 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, anti-freeze products and fuels.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: vehicles and electrical batteries and accumulators. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), rubber (e.g. tyres, shoes, toys) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

This substance is used in the following products: laboratory chemicals, coating products, fuels and pH regulators and water treatment products.

This substance is used in the following areas: scientific research and development, health services and agriculture, forestry and fishing. This substance is used for the manufacture of: , chemicals and textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: laboratory chemicals, polymers and pH regulators and water treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and manufacturing of the substance.

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products, polymers, fuels, perfumes and fragrances and water treatment chemicals.

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and formulation of mixtures.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use personal protective equipment as required.; keep container tightly closed; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If exposed or you feel unwell: call a poison center or doctor/physician.

Storage statements

Store this substance locked up.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • AB Achema, Jonalaukio km. Ruklos sen. LT55550 Jonavos r. Lithuania
  • Abbott Diagnostics GmbH, Max Planck Ring 2 D-65205 Delkenheim Hessen Germany
  • ACOMON S.R.L., VIA BAIONA, 107 48123 RAVENNA ITALY Italy
  • Acros Organics bv, Janssen Pharmaceuticalaan 3a B-2440 Geel Belgium
  • Actu-All Chemicals B.V., Randmeer 36 5347 JW OSS Netherlands
  • ADEKA Europe GmbH, Berliner Allee 22 40212 Düsseldorf Germany
  • Afton Chemical S.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • Allnex Belgium NV/SA (OR7), Anderlechtstraat 33 1620 Drogenbos Belgium Belgium
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium NV/SA OR5, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ALSG (Air Liquide Spatial Guyane), Route de l'Espace, RN 1 Bâtiment Lavoisier - BP 826 F 97388 KOUROU France
  • ANDREAS GALAXIS CO Ltd, 9, Kallistratous Street, Engomi Industrial Area 2409 Nicosia Cyprus
  • ANNO chemicals N.V., Berkenlaan 21 2980 Halle (Zoersel) (Antwerp) Belgium
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • AS DBT, Narva mnt 7D 10117 Tallinn Estonia
  • Ascensus Specialties BVBA, 23 Avenue Marnix, 5th Floor B-1000 Brussel Brussels Belgium
  • Atlantic Methanol Services B.V., Zuidplein 126 WTC Tower H, 15th Floor 1077XV Amsterdam Netherlands
  • ATLANTICA AGRICOLA S.A., La Corredera nº33 Bajo 03400 Villena Spain
  • Avantor Performance Materials Poland S.A., Sowińskiego 11 44-100 Gliwice Poland
  • AVANTOR PERFORMANCE MATERIALS POLAND SPÓŁKA AKCYJNA, Sowińskiego 11 44-101 Gliwice Silesia Poland
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • B-Lands Consulting (81111100-4), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (8111163-3), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811222-8), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811280-8), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811322-5), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811698-1), OR of Hubei Jianghan new materials Co.,Ltd 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • BaeckTrade Biokraftstoff GmbH, Hetendorf 52 29320 Hermannsburg Germany
  • Baker Hughes (Nederland) B.V, p/a Blokmakersweg 10 1786 RC Den Helder Netherlands
  • BASF Construction Additives GmbH , Dr.Albert Frank Strasse 32 83308 Trostberg Germany
  • BASF Espanola S.L., Calle Can Ràbia, n. 3-5 8017 Barcelona Spain
  • BASF Health and Care Products France S.A.S., 49, Avenue Georges Pompidou 92593 Levallois-Perret Cedex France
  • BASF Personal Care and Nutrition GmbH, Henkelstr. 67 40589 Düsseldorf Germany
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Beckman Coulter France SAS, 130, Avenue de Lattre de Tassigny 13009 Marseille France
  • Beckman Coulter GmbH, Europark Fichtenhain B13 47807 Krefeld Germany
  • Beckman Coulter Ireland Inc, Lismeehan none O'Callaghan's Mills Clare Ireland
  • Beckman Coulter, S.L.U., Plaza Europa 41-43 L'Hospitalet de Llobregat 08902 Barcelona Spain
  • Becton Dickinson Distribution Center NV, Laagstraat 57 9140 Temse Belgium
  • Bio Methanol Chemie Nederland BV, Oosterhorn 10 9936HD Farsum Netherlands
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • BNH-OIL Polska Sp. z o.o., ul.Bukowińska 22B 02-703 Warszawa Poland
  • BP Europa SE, Überseeallee 1 20457 Hamburg Germany
  • BP Europa SE, Überseeallee 1 20457 Hamburg Germany
  • BP Raffinaderij Rotterdam B.V., d'Arcyweg 76 3198 NA Europoort Rotterdam Netherlands
  • Brenntag Holding GmbH , Messeallee 11 45131 Essen Germany
  • BYK-Chemie GmbH, Abelstr. 45 DE-46483 Wesel Germany
  • C.S.B. GmbH, Dujardinstr. 5 47829 Krefeld Germany
  • CAFFARO INDUSTRIE S.P.A, P.le Marinotti, 1 33050 Torviscosa Udine Italy
  • Carbon Recycling International, Holtasmari 1 IS-201 Kopavogur Iceland
  • CATERWAYS COMPANY LTD, TRIPOLEOS 68 2235 Nicosia Cyprus
  • CBC (Europe) GmbH, Fritz-Vomfelde-Str.6 40547 Duesseldorf Germany
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • CCI Manufacturing Germany GmbH, Borsigstr. 12 41541 Dormagen Germany
  • Celanese Production Germany GmbH & Co. KG, Am Unisys-Park 1 65843 Sulzbach Germany
  • CEPSA Química, S.A., Edificio Torre Picasso Plaza Pablo Ruiz Picasso, 1 28020 Madrid Spain
  • CH.THEOTOKIS LTD, ZANETTOU 26 1100 Nicosia AYIOS ANDREAS Cyprus
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • Chemetall GmbH, Trakehner Str. 3 60487 Frankfurt Germany
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (ZIBO ZHENGDA POLYURETHANE CO., LTD), Regus Harcourt Centre HW77 D02 Dublin Ireland
  • Chemreach GmbH, Akazienweg 30 48317 Drensteinfurt Germany
  • Chemsafe srl, Via Ribes 5 10010 Colleretto Giacosa (TO) Italy
  • Chimica Pomponesco Spa, Via delle Industrie, 1 46030 Pomponesco Lombardia Italy
  • Chimitrade Spa, Piazza Duca D'Aosta 12 20124 Milano Italy
  • CHT Germany GmbH, Bismarckstr. 102 72072 Tuebingen Germany
  • Clariant Ibérica Producción S.A., Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain
  • Clariant Produkte (Deutschland) GmbH, August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • Corteva Agriscience France S.A.S., Immeuble Equinoxe 2 1bis avenue du 8 Mai 1945 78280 Guyancourt France
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Cytec Industries B.V. OR, Weena 505 3013 AL Rotterdam Netherlands
  • Cytec Industries BV, Weena 505 3013 AL Rotterdam Netherlands
  • Desatec GmbH, Raboisen 32 20095 Hamburg Germany
  • DHW Deutsche Hydrierwerke GmbH Rodleben, Brambacher Weg 1 06861 Dessau - Rosslau Saxony - Anhalt Germany
  • Dow Silicones Belgium SPRL OR-1, rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-12, Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • DSM Engineering Materials (Emmen) B.V., Urmonderbaan 22 6167RD Geleen The Netherlands Netherlands
  • DSM Nutritional Products GmbH, Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany
  • DuPont Specialty Products GmbH & Co. KG, Hugenottenallee 175 63263 Neu-Isenburg Hesse Germany
  • DuPont Teijin Films Luxembourg SA, Rue Général Patton, Contern LU-1016 Luxembourg Luxembourg
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • Ecofuel SpA, Via Felice Maritano 26 20097 SAN DONATO MILANESE Italy
  • EGIS Pharmaceuticals PLC, Keresztúri út 30-38 H-1106 Budapest Hungary
  • Equinor ASA, Forusbeen 50 N-4035 Stavanger Norway
  • Equinor Metanol ANS, Tjeldbergoddveien 100 6699 Kjørsvikbugen Norway
  • Ercros SA, Avenida Diagonal 593-595 08014 Barcelona Spain
  • ERM_GmbH_OR14_GUK, Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany
  • Europe Artis GmbH, Ludwig-Erhard-Straße 18 20459 Hamburg Germany
  • EVAL Europe, Haven 1053 Nieuwe Weg 1 - Bus 10 B-2070 Zwijndrecht Antwerp Belgium
  • Evonik Italia S.r.l., Via Falconera, 7 26025 Pandino (CR) Italy
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Operations GmbH - ME01, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Oxeno Antwerpen N.V., Tijsmanstunnel West 2040 Antwerpen Belgium
  • ExponentOR11I, Block 1, Blanchardstown Corporate Park Ballycoolen Road, Blanchardstown D15 AKK1 Dublin Ireland
  • Flexsys Chemicals Belgium NV, Scheldelaan 460, Haven 627 2040 Antwerpen Belgium
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Gelsenchem Chemical Products GmbH, Bebelallee 1 22299 Hamburg Germany
  • Glencore International Import BV, Prinses Beatrixlaan 582 2595 BM Den Haag Netherlands
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 223 63 Lund, Sweden 22363 Lund Sweden
  • Hellenic Petroleum R.S.S.O.P.P. S.A., 8A Chimarras street 15125 Marousi Attica Greece
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hexion VAD B.V., Seattleweg 17 building 4 3195ND Pernis Rotterdam Netherlands
  • HH Compliance Ltd., The Rubicon Centre, CIT Campus, 0000 Bishopstown, Cork Ireland
  • Hitachi Europe GmbH, Niederkasseler Lohweg 191 40547 Düsseldorf Germany
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Str. 40 30926 Seelze Deutschland Germany
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • Indorama Ventures Polymers Germany GmbH, Philipp Reis Strasse 4 65795 Hattersheim Germany
  • INEOS Aromatics Belgium, Amocolaan 2 2440 Geel Belgium
  • INEOS nv, Haven 1053 -- Nieuwe Weg 1 2070 Zwijndrecht Belgium
  • Innospec Performance Chemicals France SAS (Only Rep 2), Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France
  • Innospec Performance Chemicals France SAS (Only Rep 3), Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France
  • INNOSPEC PERFORMANCE CHEMICALS SPAIN S.L., Polígono Zona Franca Sector F, Calle 43 Nº 10 8040 Barcelona Spain
  • Intertek Deutschland GmbH, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 09, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 74, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • IVICT Europe GmbH, Kennedydamm 19 40476 Düsseldorf Germany
  • Jobachem GmbH, Am Burgberg 13 37586 Dassel Lower Saxony Germany
  • Kaneka Belgium N.V., Nijverheidsstraat 16 B-2260 Westerlo Antwerp Belgium
  • Kem One, IMMEUBLE LE QUADRILLE 19 RUE JACQUELINE AURIOL 69008 LYON France
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • Knoell NL-OR-047, Agro Business Park 75 6708PV Wageningen Netherlands
  • Knoell NL_OR_058, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Knoell NL_OR_059, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Kolmar NL BV, Claude Debussylaan 10 1082MD Amsterdam Netherlands
  • Kronospan Trading SRL, Str. Mihail Kogălniceanu Nr.59 floor 1, room 1/12 RO - 515800 Sebeş Alba county Romania
  • Kuraray Europe GmbH, Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • labbox labware s.l., Migjorn, 1 08338 Premia de Dalt BARCELONA Spain
  • Labcorp Development SA 014, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 032, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 148, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Leica Biosystems Nussloch GmbH, Heidelberger Straße 17-19 69226 Nussloch Germany
  • Liquid Chemicals B.V., Eerste Weteringplantsoen 8 1017SK Amsterdam Netherlands
  • Livchem Logistics GmbH, Fritz-Klatte-Strasse 8 D-65933 Frankfurt Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • LUT-SPAW Sp. z o.o., Zakrzowska 21 A 51-318 Wroclaw Poland
  • Luxcontrol S.A. (OR 60), 1, Avenue des Terres Rouges 4331 Esch-sur-Alzette Luxembourg
  • Lyondell Chemie France S.A.S., Zone Industrielle Portuaire 13270 Fos sur Mer France
  • Master Builders Solutions Deutschl. GmbH, Dr.-Albert-Frank-Strasse 32 attn. EHSQ Department 83308 Trostberg Germany
  • Mercer Stendal GmbH, Goldbecker Straße 1 39596 Arneburg Sachsen-Anhalt Germany
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • Merck Life Science AB, Frösundaviks Allé 1 16970 Solna Sweden
  • METACHEM S.p.A., Via Triboldi Pietro, 4 26015 SORESINA (CR) Italy
  • Metadynea Austria GmbH, Hafenstrasse 77 A-3500 Krems Austria
  • Methanex Europe SA/NV, Waterloo Office Park Building P Dreve Richelle 161 - Box 31 B-1410 Waterloo Belgium
  • Microban Technologies Europe Limited, 2nd Floor 1-2 Victoria Buildings Haddington Road Dublin 4 Dublin Ireland
  • MIDER-HELM Methanol Vertriebs GmbH, Nordkanalstrasse 28 20097 Hamburg Germany
  • Milliken Europe B.V., Ham 18-24 9000 Gent Belgium
  • MITSUBISHI GAS CHEMICAL EUROPE GMBH, Immermannstr.13 40210 Duesseldorf Germany
  • MITSUBISHI GAS CHEMICAL EUROPE GMBH, Immermannstr. 13 40210 Duesseldorf Germany
  • MITSUBISHI GAS CHEMICAL EUROPE GMBH, Immermannstr.13 40210 Duesseldorf Germany
  • Mitsubishi_Chemical_Europe_GmbH, Schiessstraße 47 40549 Düsseldorf Germany
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Momaja s.r.o, Karolinská 650/1 186-00 Prague 8 Czech Republic
  • Momentive Performance Materials GmbH, Chempark, Building V7 PO 4502311119 51368 Leverkusen NRW Germany
  • Momentive Performance Materials Specialties Srl, Zona Industriale- Località Rivolta Del Re Termoli 86039 Termoli CB Italy
  • Monument Chemical, Haven 1972 Ketenislaan 3 9130 Kallo Belgium
  • MOTOR OIL (HELLAS) CORINTH REFINERIES S.A., Irodou Attikou 12a 15124 Marousi Athens Greece
  • Muntajat B.V. - QAFAC, Prinses Margrietplantsoen 78-A 19th floor, Tower E, WTC The Hague 2595 BR The Hague Netherlands
  • Nafta-Petrochem d.o.o., Mlinska ulica 5 9220 Lendava Slovenia
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Neste Oyj, Keilaranta 21 FI-02150 Espoo Finland
  • Nona Trade Corporation GmbH, Schippelsweg 53 22455 Hamburg Germany
  • Nouryon Functional Chemicals B.V., Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands
  • NV DEVAN CHEMICALS, KLEIN FRANKRIJKSTRAAT 8 9600 RONSE BELGIE Belgium
  • OCI Fuels B.V. , Willemsparkweg 193 1071 HA Amsterdam Netherlands
  • OCI Methanol Marketing BV, Willemsparkweg 193 1071 HA Amsterdam Netherlands
  • OQ Trading Limited, Javastraat 6 3016 CE Rotterdam Netherlands
  • Parker Hannifin Manufacturing Germany GmbH & Co. KG, Ottostrasse 28 41836 Hueckelhoven Northrhine Westfalia Germany
  • Performance Solutions Luxembourg S.à r.l., Rue General Patton 5326 Contern Luxembourg
  • Perstorp Specialty Chemicals AB, Perstorp Industripark SE-28480 Perstorp Sweden
  • Pieris Hadjiloucas Trading Co. Ltd., 19 Smyrnis street 2540 Nicosia, Dali Cyprus
  • PMC Vlissingen Netherlands B.V., De Fruittuinen 6 2132 NZ Hoofddorp Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR13, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR7, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • Prefere Melamines GmbH, Alt Fechenheim 34 60386 Frankfurt am Main Germany Germany
  • Prefere Melamines GmbH - OR Indian Orchard, Alt Fechenheim 34 60386 Frankfurt am Main Germany
  • Prefere Resins Finland Oy, Öljysatamantie 16 49401 Hamina Finland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • Red Orchid Consulting Oy Ltd, Viherkallionkuja 3 I 59 02710 Espoo Finland
  • REG International Trading & Commodities B.V., Barbara Strozzilaan 386 1083 HN Amsterdam Netherlands
  • Regartis s.r.o., Rubeška 393/7 19000 Prague 9 Czech Republic
  • REGARTIS s.r.o., Rubeska 393/7 19000 Prague 9 Czech Republic
  • REPSOL TRADING SA, Calle Méndez Álvaro, 44 28045 Madrid Spain
  • RHODIA OPERATIONS, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France
  • Ricardo Nederland BV, Catharijnesingel 33 3511 GC Utrecht Netherlands
  • Ricoh Industrie France SAS, 144 route de Rouffach F-68920 F-68920 Wettolsheim France
  • Roche Diagnostics GmbH, Sandhoferstrasse 116 68305 Mannheim Germany
  • Ruhr Oel GmbH, Pawiker Strasse 30 45896 Gelsenkirchen Germany
  • Röhm GmbH, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • S.C. VIROMET S.A., ALEEA UZINEI 505700 VICTORIA BRASOV Romania
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • Sadepan Chimica S.r.l., Viale Lombardia, 29 46019 Viadana Italy
  • Sakura Finetek Europe B.V., Flemingweg 10A 2408AV Alphen aan den Rijn Netherlands
  • SARAS SpA, ss 195 km 19.2 09018 SARROCH (CA) SARDINIA Italy
  • Sasol Chemie GmbH & Co. KG, Anckelmannsplatz 1 20537 Hamburg Germany
  • Sasol Germany GmbH, Anckelmannsplatz 1 D-20537 Hamburg Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • SGS EWACS NV 24, Haven 1091 Keetberglaan 4 9120 Melsele Belgium
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • Shell Deutschland GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • Shell Nederland Raffinaderij B.V., Vondelingenweg 601 Postbus 3000 3190 GA Rotterdam Netherlands Netherlands
  • Shell Trading Rotterdam B. V., Weena 505 3013 AL Rotterdam Netherlands
  • Shin-Etsu Silicones Europe BV - ORA, Bolderweg 32 1332 AV Almere Netherlands
  • Siemens Healthcare Diagnostics Products GmbH, Emil-von-Behring-Str. 76 35041 Marburg Germany
  • Sigma-Aldrich Biochemie GmbH, Georg-Heyken-Str. 14 21147 Hamburg Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Ireland Ltd, Vale Road . Arklow Co. Wicklow Ireland
  • Sinopec Europa GmbH, Messe Turm Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • Sinopec Europa GmbH, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • SIPOL S.P.A, Leonardo da Vinci 5 27036 Mortara (Pavia) Italy
  • Solar Coating Solutions B.V., Urmonderbaan 22 6167 RD Geleen Netherlands
  • Solenis Netherlands B.V., Pesetastraat 62 2991 XT Barendrecht Netherlands
  • solvadis methanol gmbh, Königsberger Straße 1 60487 Frankfurt am Main Germany
  • SpetsInterProject Oy Ammoniy, Näkinkaari 1 M 02320 Espoo Finland
  • Symrise Granada, S.A.U., Crta. Armilla Km 2,5 18100 Armilla Granada Spain
  • Synthomer Trading Limited Dutch branch, Ijesselstraat 41 5347 KG Oss Netherlands
  • Sysmex Europe SE, Bornbarch 1 22848 Norderstedt Germany
  • Södra Skogsägarna ekonomisk förening, Skogsudden SE-35189 Växjö Sweden
  • TG Biochemicals Limited, 13 Konstantinou Paparigopoulu Street, Heathrow tower 3106 Limassol Cyprus
  • The Acta Group EU BVBA (BE43), Place du Luxembourg 2 1050 Brussels Belgium
  • Thermo Fisher (Kandel) GmbH, Erlenbachweg 2 76870 Kandel - Minderslachen Germany
  • TOKUYAMA EUROPE GMBH, Am Gierath 20A 40885 Ratingen Germany
  • TORAY Films Europe, Place d'Arménie 01700 Saint Maurice de Beynost France
  • TotalEnergies Petrochemicals & Refining, Rue de l'Industrie, 52 1040 Bruxelles Belgium
  • TotalEnergies Raffinerie Mitteldeutschland GmbH, MAIENWEG, 1 D06237 LEUNA Germany
  • TotalEnergies Trading Europe, 2 Place Jean Millier La Défense 6 92400 Courbevoie France
  • Trafigura Ventures V.B.V., Evert van de Beekstraat 1-82 The Base, Tower B, 5th floor 1118 CL Schiphol Netherlands
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • UAB “APLINKOS VADYBA”, Vilkpėdės g. 22 03151 Vilnius Lithuania
  • UMCO GmbH, Georg-Wilhelm-Straße 187 21107 Hamburg Germany
  • UMCO GmbH, Georg-Wilhelm-Straße187 21107 Hamburg Germany
  • V. MANE FILS , 620 route de Grasse 06620 Le Bar sur Loup France
  • V.V. ELECTRIC WORLD LTD, VASILEOS KONSTANTINOY 8021 PAFOS Cyprus
  • VALTRIS ENTERPRISES FRANCE, ZI Baleycourt 55103 VERDUN FRANCE France
  • Vantage Leuna GmbH, Am Haupttor Gebäude 7302 06237 Leuna Germany
  • VWR International BV, Haasrode Researchpark 2020 3001 Leuven Belgium
  • Wilmar Oleochemicals B.V., Merseyweg 10, Botlek 3197KG Rotterdam Netherlands
  • YOU Solutions Germany GmbH - REACH (part of Arxada), Freundallee 9 a 30173 Hannover Germany
  • [Confidential], [Confidential]
  • AGC Chemicals Europe, Ltd, World Trade Centre Zuidplein 80 1077XV Amsterdam Netherlands
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • Arrow Regulatory Ltd OR20111, 6th Floor, City Gate East Toll House Hill NG1 5FS Nottingham United Kingdom
  • Borealis AG, Trabrennstrasse 6-8 1020 Wien Austria
  • BP Oil International, Chertsey Road TW16 7BP Sunbury on Thames Middlesex United Kingdom
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • CSI-OR003, Pentlands Science Park Penicuik EH26 0PZ Edinburgh United Kingdom
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DSM Nutritional Products (UK) Ltd, Delves Road Heanor Gate DE75 7SG Heanor Derbyshire United Kingdom
  • DUBAY Polymer GmbH, Frielinghauser Strasse 5 D-59071 Hamm Germany
  • ExxonMobil Chemical Ltd., Ermyn Way ExxonMobil House KT22 8UX Surrey Leatherhead United Kingdom
  • HH Compliance Ltd., Rubicon Building, CIT-Campus Bishopstown none Cork Ireland
  • HML Europe BV, De Haal 82 1511 AT Oostzaan Netherlands
  • KEMIRA ITALY S.P.A, Via E. Majorana 8 33058 San Giorgio di Nogaro (UD) Italy
  • Knoell NL_OR_083, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Lifosa-2, Juodkiskio 50 LT-57502 Kedainiai Lithuania
  • Lifosa-4, Juodkiskio 50 LT-57502 Kedainiai Lithuania
  • Methanex UK Ltd, Eversheds House 70 Great Bridgewater Street M1 5ES Manchester Manchester United Kingdom
  • momaja s.r.o, Karolinská 650/1 186 00 Prague 8 Czech Republic
  • Momentive Performance Materials (Benelux )BVBA, Haven 1053, Nieuwe Weg 1 B-2070 Zwijndrecht Belgium
  • Nouryon Chemicals NV/SA, Parc Industriel de Ghlin Zone A 7011 Ghlin Mons Belgium
  • Nouryon Pulp and Performance Chemicals AB, Gamlestadsvägen 18 SE-415 02 Göteborg Sweden
  • OMV PETROM S.A., 22 Coralilor Street (“Petrom City”) Sector 1 013329 Bucharest Romania
  • Petrobras Global Trading B.V., Weena 798C – 23rd floor 3014 DA Rotterdam Netherlands
  • PETROBRAS GLOBAL TRADING BV - PGT BV, Weena 798C – 23rd floor First Rotterdam 3014 DA Rotterdam Netherlands
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • Raffineria di Milazzo S.C.p.A., Contrada Mangiavacca 98057 Milazzo (ME) Italy
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Roche Ireland Limited, Clarehill . Clarecastle Ireland
  • SARLUX srl, S.S. Sulcitana 195 km. 19 09018 Sarroch (CA) Sardinia Italy
  • Shell Trading International Ltd, Shell Centre SE1 7NA London United Kingdom
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom
  • Stewardship Chemicals 28, Długosza 67 43-188 Orzesze Poland
  • Total Lindsey Oil Refinery ltd, Eastfield Road DN40 3LW North Lincolnshire United Kingdom
  • Trammo SAS, 23 Rue Balzac 75008 Paris France
  • TRECO SRL, Via Romagna 8 20098 SAN GIULIANO MILANESE MILANO Italy
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • TÜV SÜD Industrie Service GmbH (37), Westendstrasse 199 80686 Munich Germany
  • TÜV SÜD Industrie Service GmbH (38), Westendstrasse 199 80686 Munich Germany
  • Videojet Technologies Europe B.V., Strijkviertel 39 3454 PJ De Meern Utrecht Netherlands
  • Vitol Chemicals BV, K.P. van der Mandelelaan 130 3062 MB Rotterdam Netherlands

Substance names and other identifiers

Methanol
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
METHANOL
C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Methyl Alcohol
Other,
metanol (es)
C&L Inventory
metanol (hr)
C&L Inventory
metanol (hu)
C&L Inventory
metanol (no)
C&L Inventory
metanol (pt)
C&L Inventory
metanol (ro)
C&L Inventory
metanol (sk)
C&L Inventory
metanol (sl)
C&L Inventory
metanol (sv)
C&L Inventory
metanol alkohol metylowy (pl)
C&L Inventory
metanoli (fi)
C&L Inventory
metanolis (lt)
C&L Inventory
metanolo alcool metilico (it)
C&L Inventory
metanols (lv)
C&L Inventory
Metanool (et)
C&L Inventory
methanol (cs)
C&L Inventory
methanol (da)
C&L Inventory
Methanol (de)
C&L Inventory
methanol (nl)
C&L Inventory
méthanol (fr)
C&L Inventory
μεθανόλη μεθυλική αλκοόλ (el)
C&L Inventory
метанол (bg)
C&L Inventory
Methanol
Registration dossier
ECHA-8600dbe1-6174-49ec-b025-9cd03d318e49
C&L Inventory
HAG Methanol C_L
C&L Inventory
Mathanol
C&L Inventory
Metanol
C&L Inventory
metanolo
C&L Inventory
methan-1-ol
C&L Inventory
METHANOL
C&L Inventory, Registration dossier, Other
Methanol
C&L Inventory, Registration dossier, Other
Methanol
Registration dossier
methanol_CAS 67-56-1
Registration dossier
Methyl alchol
Registration dossier
Methyl Alcohol
C&L Inventory, Registration dossier
Methyl alcohol
C&L Inventory, Registration dossier
Methyl alcohol, wood alcohol
Registration dossier
methylacohol
C&L Inventory
monohydroxymethane
C&L Inventory
not applicable
Registration dossier
Renewable Methanol
Registration dossier
Torque Seal Green
C&L Inventory
UPV11
C&L Inventory
12120490 Methanol
Registration dossier
alcol metilico
C&L Inventory
AZEOsolve
Registration dossier
Carbinol
Registration dossier
CR12
Registration dossier
EUROALIMENT 40
Registration dossier
MeOH
Registration dossier
METANOL
C&L Inventory
Methanol
C&L Inventory, Registration dossier
Methanol (8 CI, 9 CI)
Registration dossier
Methanol (8CI, 9CI)
Registration dossier
Methanol (8Cl, 9Cl)
Registration dossier
METHANOL BAKER ANALYZED ACS
C&L Inventory
Methanol for Biodiesel
Registration dossier
Methanol for technical use
Registration dossier
Methanol Stripping
Registration dossier
Methanol technical
Registration dossier
Methanol(8Cl, 9Cl)
Registration dossier
methanol, bio- methanol
Registration dossier
Methyl alcohol
Registration dossier
Methyl hydroxide
Registration dossier
Methylhydroxide
Registration dossier
Monohydroxymethane
Registration dossier
Renewable Methanol
Registration dossier
TEC SOL-2
Registration dossier
1173023-83-0
CAS number
Other
54841-71-3
CAS number
Other
603-001-00-X
Index number
C&L Inventory
67-56-1
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work,

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Pungent (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-97.8 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-97.8 °C

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
64.7 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
64.7 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
0.79 - 0.8 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.79

Vapour pressure

Study results
  • 2 studies submitted
  • 1 study processed
R Vapour pressure
16.927 kPa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
16.927 kPa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
-0.77 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.77 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
1 000 g/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
9.7 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
9.7 °C

Auto flammability

Study results
  • 3 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
455 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
455 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 4
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.544 - 0.59 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
17.2 days [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
17 days

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 5 studies submitted
  • 4 studies processed
R BOD5
1.067 - 1.236 g O2/g test material [2]
C Interpretation of results
Readily biodegradable (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.461 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 2 studies processed
% Distribution in Media:
R Air 12.5 - 73.3 % [2]
R Water 15.6 - 87.5 % [2]
R Soil 0 - 11.1 % [2]
R Sediment 0 - 0.02 % [2]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (1)
Intermittent releases (freshwater) No hazard identified (1)
Marine water No hazard identified (1)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) No hazard identified (1)
Sediment (marine water) No hazard identified (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil No hazard identified (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 13 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 15.4 g/L [1]
EC50 (4 days) 12.7 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 11
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 446.7 mg/L [1]
NOEC (8.333 days) 7.9 - 158 g/L [6]
LOEC (8.333 days) 7.9 - 39.505 g/L [6]
EC50 (8.333 days) 9.164 - 14.536 g/L [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3 1
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
EC50 (4 days) 18.26 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 208 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (4 days) 22 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
22 g/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
IC50 (3 h) 1 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
20 g/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 min) 71.7 g/L [1]
LC50 (4 days) 54.89 g/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (63 days) 26.646 g/kg soil dw [1]
EC50 (35 days) 17.199 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
10 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (28 days) 5.683 g/kg soil dw [1]
NOEC (28 days) 10 g/kg soil dw [1]
other: (28 days) 2.842 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg soil dw

Toxicity to terrestrial plants

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 20 g/kg soil dw [1]
EC50 (21 days) 15.492 g/kg soil dw [1]
EC50 (14 days) 15.492 g/kg soil dw [1]
EC25 (21 days) 1.808 - 12.202 g/kg soil dw [8]
EC25 (14 days) 2.823 - 5 752 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1.555 g/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 130 mg/m³ acute toxicity
Acute /short term: (DNEL) 130 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 130 mg/m³ acute toxicity
Acute /short term: (DNEL) 130 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 20 mg/kg bw/day acute toxicity
Acute /short term: (DNEL) 20 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 26 mg/m³ acute toxicity
Acute /short term: (DNEL) 26 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 26 mg/m³ acute toxicity
Acute /short term: (DNEL) 26 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4 mg/kg bw/day acute toxicity
Acute /short term: (DNEL) 4 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4 mg/kg bw/day acute toxicity
Acute /short term: (DNEL) 4 mg/kg bw/day acute toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 23
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Inhalation: 60 %

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 1 187 - 2 769 mg/kg bw (rat) [1]
LD0 2 528 mg/kg bw (rat) [1]
LD50 6 000 - 9 000 mg/kg bw (monkey) [2]
LD50 5 000 mg/kg bw (pig) [1]

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
inhalation
  • 7 studies submitted
  • 5 studies processed
P/RResults
LC50 (6 h) 82.1 - 92.6 mg/L air (rat) [3]
LC50 (4 h) 115.9 - 130.7 mg/L air (rat) [3]
LC50 (2.233 h) 79.43 mg/L air (mouse) [1]
LC50 (6 h) 43.68 mg/L air (cat) [1]
LC50 (4.5 h) 85.41 mg/L air (cat) [1]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 7
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 187 mg/kg bw
Inhalation route:
Adverse effect observed LC50 43.7 mg/L air
Dermal route:
Adverse effect observed LD50 17 100 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LOAEL (monkey): 2 340 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: inhalation
  • 11 studies submitted
  • 10 studies processed
P/RResults
NOAEL (rat): 13.3 mg/L air [1]
NOAEC (rat): 260 - 6 660 mg/m³ air [4]
NOAEC (mouse): 1.3 mg/L air [1]
NOAEC (monkey): 13 - 1 300 mg/m³ air [2]
NOEC (rat): 130 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 11
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 2 340 mg/kg bw/day (subacute, monkey)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 13 mg/m³ (chronic, monkey)

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Study data: in vivo
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence 7
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
Adverse effect observed (positive)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 1
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 1 300 mg/m³ (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Study data: developmental
  • 51 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence 46 4 1
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 1 300 mg/m³ (chronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed LOAEL 1 700 mg/kg bw/day (subchronic, mouse)
Inhalation route:
Adverse effect observed NOAEC 1 330 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant