Substance Information
Substance Information
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REACH Registration data can be found in the new ECHA CHEM database. The old ‘Registered substance factsheets’ will be available on this web site during the transition period but have not been updated since 19 May 2023. More
4,4'-methylenediphenyl diisocyanate
EC / List no.: 202-966-0
CAS no.: 101-68-8
Mol. formula: C15H10N2O2
Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.
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Possibly Carcinogenic |
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Skin sensitising |
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Respiratory sensitising |
- Substance included in the Community Rolling Action Plan (CoRAP).
- Some uses of this substance are restricted under Annex XVII of REACH.
This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.
This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
This substance is used in the following products:
adhesives and sealants and
coating products.
Other release to the environment of this substance is likely to occur from:
indoor use and
outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).
Article service life
Other release to the environment of this substance is likely to occur from:
outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and
indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
This substance can be found in products with material based on:
plastic (e.g. food packaging and storage, toys, mobile phones).
Widespread uses by professional workers
This substance is used in the following products:
adhesives and sealants and
coating products.
This substance is used in the following areas:
building & construction work,
health services and
printing and recorded media reproduction.
This substance is used for the manufacture of:
machinery and vehicles.
Other release to the environment of this substance is likely to occur from:
indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and
outdoor use.
Formulation or re-packing
This substance is used in the following products:
coating products,
inks and toners,
polymers and
cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use:
formulation of mixtures,
formulation in materials,
for thermoplastic manufacture and
in the production of articles.
Uses at industrial sites
This substance is used in the following products:
adhesives and sealants,
coating products and
polymers.
This substance is used in the following areas:
formulation of mixtures and/or re-packaging.
This substance is used for the manufacture of:
chemicals.
Release to the environment of this substance can occur from industrial use:
for thermoplastic manufacture,
in the production of articles,
in processing aids at industrial sites,
formulation of mixtures,
as an intermediate step in further manufacturing of another substance (use of intermediates) and
formulation in materials.
Manufacture
Release to the environment of this substance can occur from industrial use:
manufacturing of the substance,
formulation of mixtures and
for thermoplastic manufacture.
The InfoCard summarises the non-confidential data on substances as held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The InfoCard is automatically generated. Information requirements under different legislative frameworks may therefore not be up–to–date or complete. Substance manufacturers and importers are responsible for consulting official publications. This InfoCard is covered by the ECHA Legal Disclaimer.
about INFOCARD - Last updated: 23/12/2022