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EC number: 806-509-1
CAS number: 1393571-42-0
Pregnancy rate: 11, 10, 9 and 11 at 0, 100, 300 and 1000 mg/kg bw
Precoital interval: slightly prolonged at 300 and 1000 mg/kg bw From 1
-2 to 2 -3 days)
Gestation length: no treatment related effects (22 -23.5 day)
Mating Index: no treatment related effects (100%)
Corpora lutea: increased at 1000 mg/ kg bw
Implantation sites: increased at 1000 mg/kg bw
Pre-implantation loss: no treatment related effects
Post implantation loss: no treatment related effects
Number of offspring: increased at 1000 mg/kg bw
Twelve rats/sex were treated with the test substance (oral gavage) at 0,
100, 300 and 1000 mg/kg bw during 14 days (pre-mating), during mating
and 14 days thereafter (males). Females were further treated during
gestation and until 5 days post partum. No adverse effects on mortality,
clinical and functional observations, body weight, food and water
consumption, haematology and clinical chemistry, macroscopy, organ
weights and histopatology were found. Incidental findings reported were
within historical control values and without a dose-response
relationship. Therfore the NOAEL for parental toxiciy is considered 1000
Examination of reproductive performance (pregnancy rate, mating index,
pre-coital interval, gestation length, number of corpora
lutea/implantation sites, implantation loss) did not show any adverse
effects of the test substance. No adverse effects on the number, sex,
body weight, clinical signs of the offspring was reported. Therefore it
is concluded tht the NOAEL for reproduction is 1000 mg/kg bw.
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