Registration Dossier
Registration Dossier
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EC number: 938-716-9 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
Not expected to be carcinogenic under occupational exposure conditions.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No alerts for carcinogenicity were obtained using DEREK, Lhasa, Leeds, UK.
Additional information
· Only a limited number of glucocorticoids have been tested for carcinogenicity, but some have produced an increase in hepatocullular tumours when tested via the oral route. This is thought to be due to exaggerated pharmacological activity at high doses that are probably not relevant to occupational exposure.
· A single study reports an increase incidence of rare bone tumours in Sprague Dawley rats following two years dietary dosing at 0.25 mg/kg/day with Deflazacort, but this was not seen in a parallel study in mice.
· Available studies for fluticasone propionate and fluticasone furoate, two potent steroids, conducted via the inhalation route were negative.
No alerts for carcinogenicity were obtained using DEREK, Lhasa, Leeds, UK.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
