Registration Dossier
Registration Dossier
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EC number: 938-716-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
GSK2619294A is not considered to be acutely toxic based upon results obtained with similar materials
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
This assessment relies primarily upon read-across from structurally and functionally similar substances. An Ames screen is available together with a functional receptor screening test in order to understand its potential for interaction with the human glucocorticoid receptor.
The conclusion of the assessment relies primarily upon read across from structurally-related substances. The limited data available demonstrate similar properties to those substances and support this approach, consistent with international guidelines for read across of toxicological data (1, 2).
1. European Chemicals Agency, Guidance on information requirements and chemical safety assessment 1. Chapter R.6: QSARs and grouping of chemicals, Guidance for the Implementation of REACH.May 2008
2. OECD, Series on Testing and Assessment, Number 80, Guidance on Grouping of Chemicals, September 2007
Justification for classification or non-classification
The assessment relies primarily upon read across from structurally-related substances. The limited data available demonstrate similar properties to those substances and support this approach.
GSK2619294A is not considered to be acutely toxic based upon results obtained with similar materials, as follows:
Not expected to be toxic if ingested.
Based upon data for a wide spectrum of substances with steroidal structures and read across from CCI12778, significant acute toxicity potential is not expected with GSK2619294A
Not expected to be toxic if inhaled
Not expected to be toxic following contact with skin
•Predicted dermal penetration is low, suggesting that systemic toxicity from dermal contact is unlikely. However, in view of the relatively potent glucocorticoid activity in vitro, potential for local immunosuppressive effects and SWR from direct cannot be excluded. Other effects of direct contact with skin include itching and burning sensations, thinning of the skin and increased susceptibility to bruising.
• Substances possessing steroid structures rarely produce significant irritation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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