Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
Justification for type of information:
This attached report compiles information on LC class compounds that have been tested for acute dermal toxicity. In these assays no effects have been observed.

The test item is not harmful after single acute oral administration. The test item is structural highly similar to the LC class compounds shown in this report. There exist no additional structural elements of concern. Therefore it is justified to use the information provided in thsi report for filling the endpoint of acute dermal toxicity.

Data source

Materials and methods

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
other: read across information
Remarks on result:
other: see attached justification for details.

Applicant's summary and conclusion