Registration Dossier
Registration Dossier
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EC number: 254-075-1 | CAS number: 38668-48-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 1981
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- EC Number:
- 254-075-1
- EC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Cas Number:
- 38668-48-3
- Molecular formula:
- C13H21NO2
- IUPAC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Details on test material:
- Name of the test substance used in the study report: Dipropoxy-p-toluidin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill Ltd., Huntingdon, UK
- Diet : ad libitum
- Water : ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25°C
- Humidity (%): 40-60 %
- Photoperiod (hrs dark / hrs light):12 hours light/12 hours dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of the test material
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour after application
24 hours after application
48 hours after application
72 hours after application
7 days after application - Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 25 mm x 25 mm patch
- Type of wrap if used: elastic, adhesive dressing pervious to air
REMOVAL OF TEST SUBSTANCE
- Washing (if done): water
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Draize Evaluation of dermal irritation (according to OECD guideline 404)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-3
- Time point:
- other: 1 h, 24 h, 48 h, 72 h, 7 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1-3
- Time point:
- other: 1 h, 24 h, 48 h, 72 h, 7 days
- Score:
- 0
- Max. score:
- 4
Applicant's summary and conclusion
- Conclusions:
- After application of the test substance to the skin of rabbits no irritating effects were observed.
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