N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study preceeds current OECD guidelines, however is equivalent to OECD Guideline 404 (Acute Dermal Irritation / Corrosion). No GLP, however the study is sufficiently reported and the results unambiguous.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine

EC Number:

223-362-3

EC Name:

N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine

Cas Number:

3855-32-1

Molecular formula:

C11H27N3

IUPAC Name:

(3-{[3-(dimethylamino)propyl](methyl)amino}propyl)dimethylamine

Test material form:

solid - liquid: suspension

Details on test material:

Liquid

Test animals

Species:

rabbit

Test system

Type of coverage:

open

Preparation of test site:

other: Intact and abraded

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5ml per application

Duration of treatment / exposure:

4-72 hours

Number of animals:

3 dose groups of 6 aminals each for intact skin
3 dose groups of 6 aminals each for abraded skin
32 animal in total
No controls

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: after 4hours

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: Severely damaging to skin of Rabbits.

Results 2

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: after 4 hours

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: Severly damaging to skin of rabbits

Results 3

Irritation parameter:

edema score

Basis:

mean

Score:

>= 0 - < 1

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: Severely damaging to skin of rabbits

Irritant / corrosive response data:

Severely damaging to skin of rabbits. No recovery noted in any animal after 30-day recovery period.

Other effects:

For intact and abraded skin, at all does levels there was vocalisation and ataxia, with abraded skin animals showing more makred effects.
Increasing doses showed signs of decresed activity, prostration, lethargy ataxia, dyspnea and death.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The subsatnce is corrosive to the skin of rabbits, with no recovery afte a 30-day recovery period. The substance should be considerd corrosive to the skin and eyes, nasal and respiratory tracts.