Registration Dossier
Registration Dossier
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EC number: 223-362-3 | CAS number: 3855-32-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not performd to GLP and reporting of methods is sparse. However, the study outcomes are unambiguous and predictable. Therefore the study is deeemd sufficiently reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Whole-body exposure.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
- EC Number:
- 223-362-3
- EC Name:
- N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
- Cas Number:
- 3855-32-1
- Molecular formula:
- C11H27N3
- IUPAC Name:
- (3-{[3-(dimethylamino)propyl](methyl)amino}propyl)dimethylamine
- Test material form:
- solid - liquid: suspension
- Remarks:
- migrated information: dispersion
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats were employed as test animals. The rats were selected after having been under observation for at least 5 days to insure their general health and suitability for testing. The animals were housed in stainless steel cages and permitted a standard laboratory diet plus .water
ad libitum, except during inhalation exposure.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- Vapour was generated by passing a stream of clen, dry air through the diluted test material in a gas washing bottle. The resulting air/vapour mixture ws then introduced to the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 14 d
- Remarks on duration:
- Whole-body exposure.
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Remarks on result:
- other: No effects attributable to the test material were observed
- Mortality:
- None observed
- Clinical signs:
- other: None observed
- Body weight:
- No changes observerd outside of normal ranges
- Gross pathology:
- No gross effect reported
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- There were no adverse reactions noted during exposure or the 14-day observaticn period which followed. The average 2- week body weight gains were within the normal limits.
The LC50 was calculated as >1.48 mg/L (rat) 1-hr. (no deaths)
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