Registration Dossier
Registration Dossier
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EC number: 223-362-3 | CAS number: 3855-32-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No specific toxicokinetics studies have been performed on this substance. Toxicokinetic investigations are complicated by the corrosive effects. Oral studies in rats showed clinical and hematological parameter changes consistent with the gross tissue damage observed from feeding the animals with this substance. It is possible to surmise the metabolism of this substance, a tertiary amine. Tertiary amines as a group show a consistent hazard profile. The undiluted product is severely irritating to the eyes, skin, and mucous membranes of exposed individuals. Vapour exposure will cause immediate irritation of the eyes, mucous membranes and respiratory tract. Dermal absorption of tertiary amines is anticipated because they have low molecular weights (< 200 Daltons). These compounds are expected to be well absorbed in the respiratory and gastro-intestinal tracts. The water solubility of the substance favors extensive and even systemic distribution via the circulatory system. There is a commonality in the metabolism of the tertiary amines. N-oxide formation and excretion of both freebase and N-oxide forms, with some dealkylation, appears to be the major route of excretion for the lower molecular weight tertiary amines. The production of a number of highly water-soluble metabolites favors rapid urinary excretion and indicates that bioaccumulation is unlikely. In the Chemical Safety Report and eSDS, prevention of exposure to the substance is emphasized, and strict Risk Management Measures in advised to protect primarily against the risks of skin/eye irritation/corrosion and irritation of mucous membranes. For the purpose of Risk assessment, the absorption rates for oral, dermal and inhalation routes are set conservatively at 50, 50 and 100%,respectively.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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