N-acetylsulphanilyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary source.

Data source

Reference

Reference Type:

other: Secondary Source

Title:

Acute Oral Toxicity Study in rats

Author:

NTRL

Year:

1991

Bibliographic source:

NTRL_121608

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Equivalent or similar to OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-acetylsulphanilyl chloride

EC Number:

204-485-1

EC Name:

N-acetylsulphanilyl chloride

Cas Number:

121-60-8

Molecular formula:

C8H8ClNO3S

IUPAC Name:

4-acetamidobenzenesulfonyl chloride

Test material form:

not specified

Details on test material:

Name: 4-(Acetylamino)benzenesulfonyl chloride
CAS No.: 121-60-8
Molecular Formula: C8-H8-Cl-N-O3-S
Molecular Weight: 233.6742 g/mol
SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)Cl

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No Data Available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 2 % NaCS

Details on oral exposure:

No Data Available

Doses:

50-3200 mg/kg bw

No. of animals per sex per dose:

3 rats per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No Data Available
- Necropsy of survivors performed: No Data Available
- Clinical signs including body weight : Yes
- Other examinations performed: clinical signs, body weight

Statistics:

No Data Available

Results and discussion

Preliminary study:

No Data Available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 3 200 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

No mortality was observed after administration of the test chemical till 3200 mg/kg bw.

Clinical signs:

Clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed.

Body weight:

Normal body weight gain was observed in all the animals.

Gross pathology:

No Data Available

Other findings:

No Data Available

Applicant's summary and conclusion

Interpretation of results:

other: Not Classified as per the CLP criteria of classification and labeling.

Conclusions:

Based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.

Executive summary:

An acute oral toxicity study using the test chemical was performed using 3 animals per dose. The test chemical was administered to the rats from dose ranging from 50-3200 mg/kg bw. The test chemical was dissolved in 2% NaCS in to prepare 10% solution of the suspension. The animals were observed for 14 days, for any mortalities, clinical signs and changes in body weights. It was observed that there were no mortalities during the observation period till 3200 mg/kg bw. A few clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed. Normal body weight gain was observed in all the animals. Thus, based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.