Registration Dossier
Registration Dossier
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EC number: 203-537-0 | CAS number: 107-96-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: QSAR estimations from dermal absorption tend to be conservative; however, they are not formally validated
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: database
- Title:
- Danish QSAR Database
- Author:
- Anonymous
- Bibliographic source:
- http://ecbqsar.jrc.it/
Materials and methods
- Principles of method if other than guideline:
- The Danish QSAR Database reports DERMWINv.2 calculations. These are based on the Guy & Potts formula (GUY R.H. AND POTTS R.O., 1992. Structure-Permeability Relationships in Percutaneous absorption. J. Pharm. Sci.. 81: 603-604).
Test material
- Reference substance name:
- 3-mercaptopropionic acid
- EC Number:
- 203-537-0
- EC Name:
- 3-mercaptopropionic acid
- Cas Number:
- 107-96-0
- Molecular formula:
- C3H6O2S
- IUPAC Name:
- 3-sulfanylpropanoic acid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- MPA is predicted to have significant dermal absorption potential. SInce MPA is highly corrosive, dermal exposure must be prevented by suitable protective garment.
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