Registration Dossier
Registration Dossier
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EC number: 203-537-0 | CAS number: 107-96-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008.01.05-2008.04.24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- other substance amounts and equilibration times used
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, Consumer protection directorate, Notification Authority for Chemicals, 3003 Bern, Switzerland
- Type of method:
- other: simplified flask method
- Water solubility:
- > 603.7 g/L
- Temp.:
- 20 °C
- pH:
- ca. 1.8
- Details on results:
- Two measurements of water solubility of 3-Mercaptopropionic Acid at room temperature were performed and values 618,9 and 588.4 g/L were recorded. Water solubility was found to be more than 603.7 g/L (mean value from two measurements according to HPLC measurements within the study). Because it was not possible to prepare a saturated solution, the water solubility might be higher than determined in the present study. The water solubility was not corrected for the purity of the test item.
- Executive summary:
Water solubility has been determined to be more than 603.7 g/L by using the simplified flask method. The study followed the procedures indicated by OECD Guideline No. 105 "Water solubility" and EEC Directive 92/69 (Method A.6 "Water solubility"). Based on the high solubility found in the preliminary test a main test as described in the guideline was not performed.
Reference
Description of key information
Water solubility: >=603.7 g/L at room temperature
Key value for chemical safety assessment
- Water solubility:
- 604 g/L
- at the temperature of:
- 20 °C
Additional information
Study performed in experimental laboratory (Franke, 2008, RCC) dedicated to estimate water solubility of the test material 3-Mercaptopropionic Acid has been chosen as a key study. Water solubility has been determined to be more than 603.7 g/L by using the simplified flask method. The study followed the procedures indicated by OECD Guideline No. 105 "Water solubility" and EEC Directive 92/69 (Method A.6 "Water solubility"). Based on the high solubility found in the preliminary test a main test as described in the guideline was not performed.
Another study (Rampy, 1973, Dow) qualitatively supports the result obtained in the key study and reports complete solubility of test substance in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
