2-butylaminoethanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, brief report which meets basic scientific principles.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Each of six albino rabbits was treated dermally with 2000 mg/kg (2.24 mL/kg). Individual doses were applied to the hair-clipped skin of the trunk under a pre-fitted occluding sleeve on each animal. The sleeves were removed 24 hours later and the animals were observed for 7 days.

GLP compliance:

no

Test type:

other: 6 albino rabbits were treated dermally with 2000 mg/kg

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Butylmonoethylamine

IUPAC Name:

Butylmonoethylamine

Constituent 2

Reference substance name:

2-butylaminoethanol

EC Number:

203-904-5

EC Name:

2-butylaminoethanol

Cas Number:

111-75-1

Molecular formula:

C6H15NO

IUPAC Name:

2-(butylamino)ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Butylmonoethanolamine
- Substance type: organic (alkanolamine)
- Physical state: liquid (clear colourless, D = 0.893 g/mL)

Test animals

Species:

rabbit

Strain:

other: the only information given: albino rabbits

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Type of wrap if used: a pre-fitted occluding sleeve

REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Constant volume or concentration used: yes/no
- For solids, paste formed: yes/no

VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity:

Duration of exposure:

24 hours

Doses:

2000 mg/kg (=2.24 mL/kg bw)

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD0

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: each of the treated animals remained asymptomatic and gained body weight during the observation period.

Mortality:

no mortality

Clinical signs:

other: the animals remained asymptomatic

Gross pathology:

no data

Other findings:

no other findings reported

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

No effects were observed in treated animals after 24-hour dermal application of 2000 mg/kg bw of test material.

Executive summary:

Each of six albino rabbits was treated dermally with 2000 mg/kg (2.24 mL/kg). Individual doses were applied to the hair-clipped skin of the trunk unter a pre-fitted occluding sleeve on each animal. The sleeves were removed 24 hours later and the animals were observed for 7 days. Each of the treated animals remained asymptomatic and gained body weight during the observation period. Based on the results of the study, The LD0 of the test material is greater than 2000 mg/kg bw.