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EC number: 701-362-9
CAS number: -
1: Dermal reactions observed after application of SR 349
Rabbit number and sex (male)
E = Erythema
O = Oedema
Approximately 30 minutes after removal of the dressing
a primary dermal irritation study performed similarly to OECD Guideline
404 and in compliance with GLP, three New Zealand White male rabbits
were dermally exposed to 0.5 mL of the test substance, under a
semi-occlusive patch (25 mm X 25 mm) for 4 h to intact clipped skin of
the dorso-lumbar region. After removal of the residual test material,
animals were observed for 4 days. Irritation was scored by the method of
Draize at Day 1 (approximately 60 min after removal of the dressings)
and Days 2, 3 and 4 (equivalent to 24, 48 and 72 h) after exposure.
dermal reactions and signs of toxicity to treatment were observed in any
animal throughout the observation period. Mean individual scores at 24,
48 and 72 h after exposure for the 3 animals were respectively 0, 0, 0
for erythema and 0, 0, 0 for oedema score. In this study, the test
substance is not a skin irritant on male rabbits.
the test conditions, the test substance is not classified as irritating
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