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EC number: 701-362-9
CAS number: -
Based on the molecular mass near to 500 (mean of 483 g/mol) and a log Kow near to 4 (3.66-4.16), a dermal absorption can be estimated to be 50%.
Correction factor for difference between human and experimental exposure conditions : 7/5 (In the study, animals were exposed 7 days per week, and workers work 5 days per week).
According to ECHA Guidance – Chapter R8 : “in the absence of route-specific information on the starting route, to include a default factor of 2 (i.e. the absorption percentage for the starting route is half that the end route) in the case of oral-to inhalation extrapolation”. Therefore, as no data is available on oral or inhalation absorption, the oral absorption is estimated to 50% and the inhalation absorption to 100%. The correction factor is 0.5 (50/100).
Correction factor for differences in respiratory volume (rat/workers): 1/0.38
Correction factor for light activity at work : 6.7/10
NOAEC = NOAEL x (1/0.38) x (6.7/10) x 0.5 x 7/5= 250 x (1/0.38) x (6.7/10) x 0.5 x 7/5 = 308 mg/m3
NOAEC = oral NOAEL x (1/1.15) x 0.5 = 250 x 1/1.15 x 0.5 = 108,7 mg/m3
Dermal NOAEL = oral NOAEL x 100/50 = 250 x 100/50 = 500 mg/kg bw/day
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