Registration Dossier
Registration Dossier
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EC number: 203-818-8 | CAS number: 110-95-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data: list VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 30(5), 470-476
Materials and methods
- Principles of method if other than guideline:
- Six rats are exposed during 4hours to 1000ppm.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N,N,N',N'-tetramethyltrimethylenediamine
- EC Number:
- 203-818-8
- EC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Cas Number:
- 110-95-2
- Molecular formula:
- C7H18N2
- IUPAC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Reference substance name:
- N,N'-tetramethyltrimethylenediamine
- IUPAC Name:
- N,N'-tetramethyltrimethylenediamine
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
- Name of test material (as cited in study report): N,N,N',N'-tetramethyl-1,3-propane diamine
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
- Other: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing:no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum):no data
- Acclimation period:no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To:no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: no data
- Method of holding animals in test chamber: no data
- Source and rate of air: no data
- Method of conditioning air: no data
- System of generating particulates/aerosols:no data
- Method of particle size determination: no data
- Treatment of exhaust air:no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: no
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 1000 ppm (5.32 mg/L)
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1 000 ppm
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 5.32 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- 2/6
- Clinical signs:
- other: No data
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under these experimental conditions, the inhalation LC50 of TMPDA is higher than 1000 ppm (5.32 mg/l) in male.
- Executive summary:
The Acute inhalation toxicity of Tetramethylpropylenediamine (TMPDA) was evaluated in one group of 6 rats. The 4-hour exposure at 1000 ppm caused death in 2/6rats.
Under these experimental conditions, the inhalation LC50 of TMPDA is higher than 1000 ppm (5.32 mg/l) in male.
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