Registration Dossier
Registration Dossier
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EC number: 203-057-1 | CAS number: 102-81-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Does not significantly accumulate in organisms.
Key value for chemical safety assessment
Additional information
According to Regulation (EC) 1907 (2006) Annex IX, Section 9.3.2, Column 2, a study on bioaccumulation does not need to be conducted as the substance has a low potential for bioaccumulation. The substance has an experimentally determined log Kow of 1.86 (@20°C, pH 9.2, BASF AG, 1993, report no. 93P00886.07). Regarding these values, accumulation of the test substance in organisms is not to be expected. Therefore, and for reasons of animal welfare, a study on bioaccumulation is not performed.
However, the bioaccumulation potential of DBEA was investigated in a GLP-study according to OECD 305C using Cyprinus carpio as test species (NITE 2001, report no. A010219). The BCF(steady state) was determined to be < 39 L/kg at a concentration of 0.02 mg/L (< 5 L/kg at 0.2 mg/L). The test concentrations were analytically verified. Based on these test results it can be concluded that the substance does not accumulate significantly.
This experimental result is supported by calculated data of two BCF models:
- EPISuite v4.11/BCFBAFv3.01: A BCF value of 7.8 L/kg was estimated on the basis of the log Kow of 1.86 (measured) (BASF SE, 2017). The substance falls within the applicability domain of the model.
- Catalogic v5.13.1, BCF base-line model v03.10: The substance was 100% within the applicability domain of the model. The BCF was estimated to be 33.6 L/kg (log BCF = 1.53) without considering any mitigating factors. Metabolism, molecular size and water solubility had a mitigating effect on the bioaccumulation potential. The BCF was estimated to be 3.7 L/kg (log BCF = 0.57; BASF SE, 2019) if mitigating effects were considered.
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