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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Lithium Chloride
Year:
1980
Bibliographic source:
Acta Pharmacologica et Toxicologica 47, 351, 1980 (APTOA6); via RTECS

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Only data from review article available. No guideline or method indicated.
GLP compliance:
not specified
Test type:
other: not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium chloride
EC Number:
231-212-3
EC Name:
Lithium chloride
Cas Number:
7447-41-8
Molecular formula:
ClLi
IUPAC Name:
lithium chloride

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
The rats were 3 weeks, 6 weeks, 3 months and 6 months old.

Administration / exposure

Details on oral exposure:
Lithium chloride was given intraperitoneally, subcutaneously and orally.
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
Not applicable
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
526 mg/kg bw
Based on:
test mat.
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

In relation to age, LD50 was significantly higher in rats of 6 weeks after oral administration than LD50 in rats of 3 and 6 months. No differences were found following intraperitoneal and subcutaneous administration. In relation to route of administration, LD50 was significantly higher in rats of 3 and 6 weeks after oral administration than LD50 after intraperitoneal and subcutaneous administration. This difference was not found in rats of 3 and 6 months. It is concluded that age and route of administration are of significance for LD50 of Lithium chloride in the rat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
According to the review article, the LD50 of lithium chloride is 526 mg/kg bw after oral administration to rats.
Executive summary:

According to the reviewarticle, the LD50 of lithium chloride is 526 mg/kg bw after oral administration to rats.