Registration Dossier
Registration Dossier
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EC number: 231-212-3 | CAS number: 7447-41-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The absorption of lithium through skin is considered to be very poor.
- Executive summary:
Expert statement: Due to the chemical properties of an inorganic salt, the dermal absorption of lithium chloride is expected to be very poor. Based on (1) the hydrophilic character of lithium chloride and (2) the barrier function of the stratum corneum against salts, dermal absorption can practically be excluded. Dermal toxicity values revealed LD50 values > 2000 mg/kg bw, which further supports this conclusion. 10% absorption was used for DNEL deduction. Thus, this presents a worst case.
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