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EC number: 203-770-8
CAS number: 463-04-7
The LC50 ppm has been converted to mg/L with
the following equation:
C (ppm) = mol. volume (24.45) /mol weight *
716 ppm = 24.45/117 * C (mg/m³)
C (mg/m³) = 3426 mg/m³ = 3.426 mg/L
The acute inhalative toxicity for the test
item in the rat was investigated in an acute toxicity inhalation test
(published by Klonne et al.) according to international standard
protocols. 5 female rats and 5 male rats were exposed to a vapour of the
test item in an 54 -litre glass chamber for 4 hours. Exposure
atmospheres for the test item was generated by vaporization of the
liquid on a glass bead column.
The 4-hr inhalation LC50 was determined for
methyl-, ethyl-, n-propyl-, n-butyl-, isobutyl-, and isopentyl nitrite
in Sprague-Dawiey rats. LC50 values were 176, 160, 300, 420, 777, and 716
ppm, respectively. The dose-mortality curves were characterized by
extremely steep slopes. Toxic signs observed during exposure included
cyanosis, prostration, and rarely, convulsions. There were no effects of
exposure on body weight gain during a 14-day postexposure observation
period. Signs of pulmonary hemorrhage were apparent in rats which died
during exposure but were much less prominent in rats sacrificed at study
termination. No animals died after cessation of exposure, and rapid
recovery was apparent after exposure. Concentration X Time (CT)
relationships suggested that the actual concentration was more important
than the "dose" in determining the lethal effects of inhalation exposure
to nitrites. Because of the extremely steep dose-mortality curves, the
aliphatic nitrites are more hazardous than the LC50 values would
indicate. The LC50 (4h) in the rat for the test item was determined to
be 716 ppm (3.426 mg/L). Impacts resulting from the corrosiveness of the
substance cannot be excluded.
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