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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 Apr - 10 Apr 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance
Temp.:
20 °C
Vapour pressure:
0.007 Pa
Temp.:
25 °C
Vapour pressure:
0.011 Pa
Temp.:
50 °C
Vapour pressure:
0.095 Pa

Thermal Stability

The test item showed two endothermic effects in the temperature ranges of 110 °C to 160 °C and 220 °C to 330 °C, respectively. An exothermic was observed in the temperature range of 350 °C to 400 °C with a mean decomposition energy of -100 J/g.

Table 1: Results of the DSC-measurement

Sample weight / mg

Start of effect / °C

Energy*/ (J/g)

5.27

130
230
360

+50 (endothermic)
+140 (endothermic)
-90 (exothermic)

6.61

110
220
350

+60 (endothermic)
+190 (endothermic)
-100 (exothermic)

* Different from the convention applied in the thermograms, energies of exothermic effects are presented as negative values and energies of endothermic effects as positive values.

Effusion method: Vapour pressure balance

The vapour pressure was measured in the temperature range of 43 °C to 73 °C. The measured vapour pressure values together with the measured temperatures are listed in Table 2.

Table 2:      Results of the Effusion method

No.

Temperature / °C

Vapour pressure / Pa

1

43

5.29 × 10-2

2

48

7.69 × 10-2

3

53

1.18 × 10-1

4

58

1.90 × 10-1

5

63

2.78 × 10-1

6

68

3.70 × 10-1

7

73

4.84 × 10-1

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation can be derived by regression of the data points to

A = 10.1754

B = -3619.13

C = 273.15.

The vapour pressure of the test item DMPSA-K2 calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. Vapour pressureand OECD Test Guideline 104 (2006) is shown in Table 3:

Table 3: Calculated vapour pressure values for 20, 25 and 50 °C

Temperature / °C

Vapour pressure / Pa

20

6.8 × 10-3

25

1.1 × 10-2

50

9.5 × 10-2

Final Results

The vapour pressure of the test item DMPSA-K2 was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4.Vapour pressureand OECD Test Guideline 104 (2006).

Temperature / °C

Vapour pressure / Pa

20

6.8 × 10-3

25

1.1 × 10-2

50

9.5 × 10-2

 

 

Description of key information

6.8E-3 Pa at 20 °C (vapour pressure balance, OECD 109)

Key value for chemical safety assessment

Vapour pressure:
0.007 Pa
at the temperature of:
20 °C

Additional information