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PBT assessment

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PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB
Justification:

The PBT Assessment for Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2017).

Persistence

Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate is expected to dissociate under environmenal conditions forming K+ and the conjugate acid (Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid; CAS 2241455-89-8). The conjugate acid is not readily biodegradable but will be rapidly degraded to 3,4-dimethylpyrazole (DMP) with normalized half-lives of 1.5 - 3.3 d (OECD 307, 28 d). For the metabolite DMP normalized half-lives of 3.8 - 8.9 d in soil were determined. QSAR calculations predicted ready biodegradability in water for the metabolite DMP. Thus, Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate as well as the conjugate acid and its degradation product DMP do not meet the P/vP criteria.

Bioaccumulation

The experimentally determined log Pow of Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinat is -2.5. Thus the substance does not meet the screening criteria for B or vB.

Toxicity

The available NOEC (21 d) for Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinat is > 0.01 mg/L (read-across). The substance is not classified according to the consolidated version of Regulation (EC) No 1272/2008 for environmental or human health hazards. Thus, the substance does not meet the T criterion. 

In conclusion: the substance is not PBT/vPvB.