4-(4-isopropoxyphenylsulfonyl)phenol

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 1988-08-23 to 1988-12-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

yes

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

No sampling procedure indicated.

Buffers:

McIlvaine buffer solution for pH 4:
0.1 M citric acid + 1 N sodium hydroxide (8:2) (55.1 mL)
0.1 N hydrochloric acid (44.9 mL)
Distilled water (950 mL)

Soerensen buffer solution for pH 7:
M/15 potassium phosphate, monobasic (41.3 mL)
Sodium phosphate, dibasic (58.7 mL)
Distilled water (950 mL)

Clark and Lubs buffer solution for pH 9:
0.005 M borax (417 mL)
0.1 N hydrochloric acid (83 mL)
Distilled water (500 mL)
Adjusted to pH 9 with 0.1 N NaOH

Details on test conditions:

The test solutions at the indicated pH values were stored at 50 ± 1 °C for the required time (24, 48, 72, 96 and 120 hours).

Duration:

24 h

Temp.:

50 °C

Initial conc. measured:

14.68 mg/L

Remarks:

pH 4, 7 and 9

Duration:

48 h

Temp.:

50 °C

Initial conc. measured:

14.68 mg/L

Remarks:

pH 4, 7 and 9

Duration:

96 h

Temp.:

50 °C

Initial conc. measured:

14.68 mg/L

Remarks:

pH 4, 7 and 9

Duration:

120 h

Temp.:

50 °C

Initial conc. measured:

14.68 mg/L

Remarks:

pH 4, 7 and 9

Number of replicates:

Two measurements were performed per pH condition.

Positive controls:

no

Negative controls:

no

Preliminary study:

The results of the preliminary test indicated in the guideline showed that the recovery of D-8 was more than 96 % after 5 days at 50 °C and pH 4, 7 and 9. Thus, it was concluded that D-8 is hydrolytically stable.

Transformation products:

not measured

% Recovery:

> 96 - < 102

pH:

4.07

Temp.:

50 °C

Duration:

>= 24 - <= 120 h

Remarks on result:

hydrolytically stable based on preliminary test

% Recovery:

> 97 - < 102

pH:

7.1

Temp.:

50 °C

Duration:

>= 24 - <= 120 h

Remarks on result:

hydrolytically stable based on preliminary test

% Recovery:

> 97 - < 102

pH:

8.92

Temp.:

50 °C

Duration:

>= 24 - <= 120 h

Remarks on result:

hydrolytically stable based on preliminary test

Key result

Remarks on result:

hydrolytically stable based on preliminary test

Details on results:

The hydrolysis of D-8 in aqueous solutions was tested in accordance with OECD Guideline 111. The results of the preliminary test indicated in the guideline showed that the recovery of D-8 was more than 96 % after 5 days at 50 °C and pH 4, 7 and 9. Thus, it was concluded that D-8 is hydrolytically stable.

The recovery of D-8 under each condition in this experiment is summarized in the table.

The recoveries at any pH were more than 96 % for 5 days and more than 99 % at 5 days.

Therefore, it was concluded that D-8 is stable at 50 °C in acidic, neutral and basic solutions.

Table: Recovery of D-8 in Hydrolysis Study.

 

Incubation time	Recovery ( % of applied D-8*) at pH
(hrs)	pH	4.07	7.10	8.92
0	1	96.0**	97.9	100.8
	2	96.7	101.9	101.4
	Av.	96.4	99.9	101.1
24	1	102.3	100.3	99.2
	2	101.7	101.8	99.2
	Av.	102.0	101.1	99.2
48	1	99.9	100.0	100.2
	2	101.7	101.6	100.7
	Av.	100.8	100.8	100.5
72	1	101.1	100.6	97.7
	2	100.1	101.3	98.0
	Av.	100.6	101.0	98.0
96	1	99.9	98.8	100.2
	2	100.4	100.8	100.3
	Av.	100.2	99.8	100.3
120	1	102.4	99.5	99.9
	2	101.3	99.3	98.5
	Av.	101.9	99.4	99.2

 

* Initial concentration of D-8 : 5.02E-5 M (14.68 mg/L).

** Figures are mean values of 2 measurements.

Validity criteria fulfilled:

yes

Conclusions:

D-8 was tested for hydrolytic stability in aqueous solutions at pH 4, 7 and 9 according to OECD Guideline 111. The results of the preliminary test showed that the recovery of D-8 was more than 96 % for 5 days at 50 °C and pH 4, 7 and 9. It was concluded that D-8 is hydrolytically stable.

Executive summary:

D-8 was tested for hydrolytic stability in aqueous solutions according to OECD 111. The pH values tested were 4, 7 and 9. The samples were incubated at 50 °C for 24, 48, 72, 96 and 120 hours. The results showed a recovery of D-8 of more than 96 % for 5 days at 50 °C. Thus, it was concluded that D-8 is hydrolytically stable.

Description of key information

D-8 is hydrolytically stable at pH 4, 7 and 9.

Additional information

D-8 was tested for hydrolytic stability in aqueous solutions according to OECD 111. The pH values tested were 4, 7 and 9. The samples were incubated at 50 °C for 24, 48, 72, 96 and 120 hours. The results showed a recovery of D-8 of more than 96 % for 5 days at 50 °C. Thus, it was concluded that D-8 is hydrolytically stable.