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EC number: 701-354-5
CAS number: -
OD 570 nmWell 1
OD 570 nmWell 2
Mean OD of 2 Wells
of 2 Wells blank
of 3 tissues
Rel. Viability [%] Tissue1, 2 + 3*
of viability values
Mean Rel. Viability
* Relative viability [rounded values]: [100 x (absorbance test item/
postive control/ negative control)]/ mean absorbance negative control
** Mean relative viability [rounded values]: [100 x (mean absorbance
test item/ postive control/ negative control)]/ mean absorbance negative
This in vitro study was performed to assess the irritation potential of
Sodium cocopropylenediamine propionate, CAS 97659-50-2 by means of the
Human Skin Model Test according to OECD TG 439.
The test item did not reduce MTT (pre-test for direct MTT reduction),
and it did not dye water, when mixed with it (pre-test for colour
interference). Also its intrinsic colour was not intensive.
Consequently, additional tests with freeze-killed or viable tissues were
Three tissues of the human skin model EpiSkin™ were treated with the
test item, the negative control (PBS) or the positive control (5% sodium
lauryl sulfate) for 15 minutes.
After treatment with the negative control the absorbance values were
well within the required acceptability criterion of mean OD 0.6 till ≤
1.5 thus showing the quality of the tissues.
Treatment with the positive control induced a sufficient decrease in the
relative absorbance as compared to the negative control thus ensuring
the validity of the test system.
After treatment with the test item the mean relative absorbance value
was 100.6%. This value is above the threshold for irritancy of ≤ 50%.
Therefore, the test item is not considered to possess an irritant
In conclusion, it can be stated that in this study and under the
experimental conditions reported, Sodium cocopropylenediamine
propionate, CAS 97659-50-2 is not irritant to skin according to UN GHS
and EU CLP regulation.
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