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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

GDMA is considered non-genotoxic in vitro based on read-across from structurally related compounds.

Link to relevant study records

Referenceopen allclose all

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
see category report attached as "full study report"
Principles of method if other than guideline:
read across using OECD QSAR Toolbox
Type of assay:
bacterial reverse mutation assay
Metabolic activation:
with and without
Key result
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)
Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
see category report attached as "full study report"
Principles of method if other than guideline:
read across using OECD QSAR Toolbox 4.2
Type of assay:
in vitro mammalian chromosome aberration test
Key result
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)
Conclusions:
negative based on read across
Endpoint:
in vitro gene mutation study in mammalian cells
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
see category report attached as "full study report"
Principles of method if other than guideline:
read across using OECD QSAR Toolbox 4.2
Type of assay:
mammalian cell gene mutation assay
Key result
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)
Conclusions:
negative based on read across
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Description of key information

GDMA is considered non-genotoxic in vivo based on read-across from structurally related compounds.

Link to relevant study records
Reference
Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Justification for type of information:
see category report attached as "full study report"
Type of assay:
micronucleus assay
Key result
Genotoxicity:
negative
Remarks on result:
other: read across
Conclusions:
negative based on read across
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Justification for classification or non-classification

Read-across from numerous in-vitro and in-vivo studies on related compounds does not suggest a genotoxic hazard.