Registration Dossier
Registration Dossier
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EC number: 281-928-5 | CAS number: 84066-92-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
3 mutagenicity studies are available for formaldehyde, reaction products with ethylendiamine: an Ames test, a Mouse Limphoma assay and a Chromosom Aberration test. The Amest test resulted inconclusive, while the other two studies resulted positive with and without metabolic activation.
Justification for selection of genetic toxicity endpoint
Two of the 3 studies available were positive, while 1 study was inconclusive.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Basing on the results of the 3 in vitro mutagenicity studies, formaldehyde, reaction products with ethylendiamine resulted probably positive for mutagenicity, but no final conclusion can be formulated. The final classification would be confirmed by a in vivo mutagenicity study, therefore at present, no final classification can be assigned.
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