Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline method according to GLP, documentation is incomplete.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Remarks:
- Principles of GLP, UK GLP methods
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Isopropyl benzoate
- EC Number:
- 213-361-6
- EC Name:
- Isopropyl benzoate
- Cas Number:
- 939-48-0
- Molecular formula:
- C10H12O2
- IUPAC Name:
- propan-2-yl benzoate
- Reference substance name:
- IPB
- IUPAC Name:
- IPB
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): Isopropyl Benzoate
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Remarks:
- DI water
- Details on oral exposure:
- VEHICLE: Water
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/Kg - Doses:
- Single dose 2000 mg/KG
- No. of animals per sex per dose:
- Five male and five female rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Every day for 14 days
- Other examinations performed: clinical signs, body weight and any other signs of toxicity observed and recorded. AT the end of the study the animals were killed and macroscopically examined post mortem.
Results and discussion
- Preliminary study:
- There were no deaths and no significant signs of toxicity. Acute oral median dose is in excess of 2000 mg /Kg
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: No clinical toxicity signs were observed
- Other findings:
- - Other observations: No deaths, toxicity or significant findings at post mortem.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute oral LD50 dose of IPB is in excess of 2000 mg /kg.
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