Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Endpoint summary
Administrative data
Description of key information
Benzoic acid occurs naturally in foods, and benzyl derivatives are approved food additives with an ADI of 0-5 mg/kg bw/d.
Additional information
Benzoic acid occurs naturally in plants and many foods, including fruits (berries), vegetables, meats, cheeses and milk products, and wine. JECFA, EFSA and the U.S. FDA have approved benzyl derivatives as food additives and flavourings with an acceptable daily intake (ADI) of 0 -5 mg/kg bw/d (combined). Cases of urticaria, asthma, rhinitis, or anaphylactic shock have been reported following oral, dermal, or inhalation exposure to benzoic acid and sodium benzoate. In the general human population, adverse health reactions to benzoic acid and sodium benzoate are rare. Sodium benzoate has been used therapeutically in patients with urea cycle abnormalities, at a dose range of 250-500 mg/kg bw/d, without significant adverse effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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