Registration Dossier
Registration Dossier
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EC number: 216-407-3 | CAS number: 1576-35-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin irritation and the available information indicates that it should be classified as eye irritation (Category 2)
- Justification for type of information:
- No reliable experimental data is available for Toluene-4-sulphonohydrazide (TSH). However, the presumed breakdown product toluene-4-sulphonic acid (CAS No. 104-15-4) has a harmonized classification for Eye Irrit. 2, H319. Furthermore, toluene-4-sulphonic acid is considered to be able to induce sever eye damage since 593 notifiers in the ECHA CLP database have classified the substance as Eye Dam.1. Likewise, hydrazine (CAS No. 302-01-2), another breakdown product of Toluene-4-sulphonohydrazid, is considered to be able to induce severe eye damage since 596 notifiers in the ECHA CLP database have classified the substance as Eye Dam.1. Based on the effect to the eyes of the breakdown products it is considered appropriate to classify the substance as Eye Irrit. 2 here without further testing.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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