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EC number: 221-312-5
CAS number: 3064-73-1
In an acute oral toxicity study (17/053-001P), Crl:WI Wistar female rats
(3/dose) were given TiBTD (97%) in 1% methyl cellulose at doses of 2000
mg/kg bw and observed for 14 days.
LD50 (female): was >2000 mg/kg bw.
Initially, 3 females were treated at a dose level of 2000 mg/kg bw. As
no mortality was observed, a confirmatory group of 3 females was treated
at the same dose level. TiBTD did not cause mortality at a dose level of
2000 mg/kg bw in any animal. All animals were symptom-free during the
observation period at a dose level of 2000 mg/kg bw. Body weight gains
of TiBTD treated animals during the study showed no indication of a test
item-related effect. There was no evidence of the macroscopic
observations in animals dosed at 2000 mg/kg bw and subjected to the
necropsy on Day 14.
This acute oral study is classified as acceptable. It does satisfy the
guideline requirement for an acute oral study (OECD 423) in the rat.
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