Registration Dossier
Registration Dossier
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EC number: 947-394-9 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28th March - 6th June 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- Commission Directive 92/69/EEC
- Deviations:
- yes
- Remarks:
- Only the preliminary test was performed
- Principles of method if other than guideline:
- As the flask shaking and HPLC methods proved unsuitable for determining the partition coefficient of the test item, the result was determined from the solubilities in the pure solvents, as detailed in the preliminary test in Method A.8 of Commission Directive 92/69/EEC.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: visual inspection of separate solutions of the test item in water and in n-octanol
- Key result
- Type:
- log Pow
- Partition coefficient:
- > -3.51 - < -3.48
- Temp.:
- 20 °C
- pH:
- ca. 4.7
- Conclusions:
- The log Pow, estimated based on the test item solubility in n-octanol and in water, is approximately -3.5.
Reference
Solubility in water = 475 - 500 g/L
Solubility in n-octanol = 155 mg/L
Pow = 3.26E-04 - 3.1E-04
Description of key information
The estimated Log Pow is -3.5.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.5
- at the temperature of:
- 20 °C
Additional information
The log Pow of the test item was determined from the solubilities in water and in n-octanol, as detailed in the preliminary test in Method A.8 of Commission Directive 92/69/EEC. This was due to the unsuitability of the shake flask and HPLC methods for this substance. The estimated Log Pow was -3.5.
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