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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Analytical monitoring:
yes
Vehicle:
yes
Test organisms (species):
Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Details on test organisms:
Desmodesmus subspicatus CHODAT (SAG 86.81) from the SAG Culture Collection at the University Göttingen
Test type:
static
Water media type:
freshwater
Test temperature:
22.8 to 23.3°C.
pH:
7.1-7.5
Nominal and measured concentrations:
100,50,25,12.5,6.25mg/l
Details on test conditions:
Light intensity is continuously variable and was set on 45% of the maximum light intensity resulting in a mean light intensity of 120 μE/m2 s +/- 3.6% (PAR, measured by a spherical sensor).
Reference substance (positive control):
yes
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
46.3 mg/L
Nominal / measured:
nominal
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
20.4 mg/L
Nominal / measured:
nominal
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
12.5 mg/L
Nominal / measured:
nominal
Basis for effect:
growth rate
Details on results:
During the test course ISELUX was stable. Recovery rate was determined between 97.3% and 101.7%.
Validity criteria fulfilled:
yes
Conclusions:
In a study according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/L

Description of key information

In a study performed according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/l


In a study performed to EPA OPPTS 850.5400, on the read across material SCMI, a NOEC of <0.1 mg/L and an LC50 of >1000 mg/L based on cell number (nominal concentrations) was achieved

Key value for chemical safety assessment

EC50 for freshwater algae:
46.3 mg/L
EC10 or NOEC for freshwater algae:
12.5 mg/L

Additional information

In a key study performed according to OECD 201, SLMI has a EC50 of 46.3 mg/L (Growth Rate) and a NOEC of 12.5mg/l.

In a supporting study performed to EPA OPPTS 850.5400, on the read across material SCMI, a NOEC of <0.1 mg/L and an LC50 of >1000 mg/L based on cell number (nominal concentrations) was achieved