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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EPA OPP 72-1 (Fish Acute Toxicity Test)
GLP compliance:
yes
Vehicle:
yes
Details on test solutions:
- Concentration of vehicle in test medium: 0, 0.1, 1.0, 10 100 and 1000 mg/L
Test organisms (species):
Pimephales promelas
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
Reconstituted water with total hardness between 40 and 180 mg CsCO3
Test temperature:
22 +- 1C
pH:
Between 6.0 and 8.0
Dissolved oxygen:
At least 60% saturation
Nominal and measured concentrations:
Concentrations of 0.1, 1.0, 10, 100 and 1000 mg/L
Details on test conditions:
TEST SYSTEM
- Test vessel:
- Type open
- Material, fill volume: Glass 1L
- No. of organisms per vessel: 10 fish
- No. of vessels per concentration: 3
- No. of vessels per control: 3
- Biomass loading rate: maximum loading of 0.8g fish/litre


Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
29.3 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality
Remarks on result:
other: 95% CL 25.2-34.1 mg/L
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
10 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

A 100% survival rate was observed in the Pimephales promelas treated with 0.1 and 1.0 mg/L. A 97% survival rate was seen in the 10 mg/L concentration group. No fish treated with 100 or 1000 mg/L had survived at the 6 hour observations.

Validity criteria fulfilled:
yes
Conclusions:
In a study performed to EPA OPP 72-1 (Fish Acute Toxicity Test), the 96-hour LC50 of Sodium Cocoyl Methyl Isethionate was 29.3 mg/L with 95% confidence limits of 25.2-34.1 mg/L

Description of key information

In a study performed to EPA OPP 72-1 (Fish Acute Toxicity Test), the 96-hour LC50 of Sodium Cocoyl Methyl Isethionate was 29.3 mg/L

Key value for chemical safety assessment

LC50 for freshwater fish:
29.3 mg/L

Additional information

In a study performed to EPA OPP 72-1 (Fish Acute Toxicity Test), the 96-hour LC50 of Sodium Cocoyl Methyl Isethionate was 29.3 mg/L with 95% confidence limits of 25.2-34.1 mg/L