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EC number: 701-083-2
CAS number: -
Table1 Summary of opacity, permeability andin
MeanIn vitroIrritation Score1, 2
MEA Polyborate 1:1
using the negative control mean opacity and mean permeability values.
vitro irritancy score (IVIS) = mean opacity value + (15 x mean OD490value).
Screening for the eye irritancy potential of MEA Polyborate 1:3
using the Bovine Corneal Opacity and Permeability test (BCOP test).
This summary describes the ocular irritation properties of MEA
Polyborate 1:3 on an isolated bovine cornea. The possible ocular
irritancy of MEA Polyborate 1:3 was tested through topical application
for 10 ± 1 minutes.
Batch EU-01696 of MEA Polyborate 1:3 was a clear
colourlessliquidwith a purity of 68% salt in water. The test substance
was applied as it is (750 µl) directly on top of the corneas.
The negative control responses of the opacity and permeability
values were less than the upper limits of the laboratory historical
rangeindicating that the negative control did not induce irritancy on
the corneas.The meanin vitroirritancy score of the positive
control (10% (w/v) Benzalkonium Chloride) was 144 and was within the
historical positive control data range.It was therefore concluded that
the test conditions were adequate and that the test system functioned
MEA Polyborate 1:3 did notinduce ocular irritation through both
endpoints, resulting in a meanin vitroirritancy score of 0.0
after 10 minutes of treatment.
Finally, it is concluded that this test is valid and that MEA
Polyborate 1:3 is not severe irritant or corrosive in the Bovine Corneal
Opacity and Permeability test under the experimental conditions
described in the report.
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