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EC number: 701-083-2
CAS number: -
Mean scores for erythema and oedema (calculated from the values recorded
at the 24,48 and 72 hour readings) were used.
The purpose of this study was to assess the degree of irrititaion
produced by the test article when applied to the skin of the albino
rabbit. The procedures e used were in accordance with EEC Annex V
A 0.5 aliquot of the test article was applied over a previouslly clipped
area of about 6 sq cm of the dorsal skin of each of 3 albino rabbits.
The test article was held in contact with the skin, under a
semi-occlusive patch assembly, for a 4 hour period. The patches were
then removed and skin reaction assessed after one, 24, 48 and 72 hours.
The treated site on 2 of the 3 rabbits remained free from apparent
irritation throughout the 72 hour observation period. A barely
perceptable erythema was noted at the treated site on the third animal
one and 24 hours after patch removal but was no longer apparent at the
48 and 72 hour examinations.
The test article did not produce significant irritation in any animal.
According to the criteria described in EEC Commision Directive
91/325/EEC of 1st March 1991, the test article would not require
labelling with either of the risk phrases "R34 Causes burns" or "R38
Irritating to skin" under the conditions of this study.
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