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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Patty´s Industrial Hygiene and Toxicology
Author:
Hine, Rowe, White, Darmer, Jr. and Youngblood
Year:
1981
Bibliographic source:
3rd ED. 1981 Vol II A, page 2237- 2240

Materials and methods

Principles of method if other than guideline:
The information does not come from a test report and the minimum fields can not be filled in.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Polyglycidyl ether of substituted glycerine (EPON 562)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intramuscular
Frequency of treatment:
6 doses
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 and 0.2 g/kg

Results and discussion

Results of examinations

Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
No information is available concerning methods used, guidelines followed. However, as the data comes from a peer-reviewed handbook, the information is considered to be of high quality (reliability Klimisch 2). The test material did not induce any effects at 0.1 g/kg but at 0.2 g/kg depression of white cell count and bone marroy nucleated cell count were noted after application of the test substance to rats at 0.1 and 0.2 g/kg intramuscularly for 6 applications.
Executive summary:

The Patty´s Industrial Hygiene and Toxicology also contains information about 1,2,3 -propanetriol, glycidyl ethers (Patty's Industrial Hygiene and Toxicology, 3erd Ed, Hine et al., 1981). There a study is mentioned, where the test substance was administered intramuscular to rats at 0.1 and 0.2 g/kg for 6 applications. No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count.