Registration Dossier
Registration Dossier
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EC number: 946-378-9 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Test start date: 13 February, 1990; Test end date: 21 May, 1990; Study completion date: 25 June, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Code number of the test material as used in the study report: Methine Blue TRL; FAT 31064/F
According to the analytical certificate the test compound consists to about 50 % of the cationic acetate. The other half is in the hydrolyzed OH form (carbinol base).
- Source and lot No.of test material: EN 158496.82/ HEW 133/6 - Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.99
- Temp.:
- 25 °C
- pH:
- 2.1
- Type:
- Pow
- Partition coefficient:
- 9.8
- Temp.:
- 25 °C
- pH:
- 2.1
- Conclusions:
- The n-octanol/water partition coefficent of the test item at 25 °C was determined to be (log Pow) 0.99.
- Executive summary:
A test was conducted to determine the n-octanol/water partition coefficient of the test substance according to the OECD Guideline 107 and EU Method A.8. The shake flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition coefficent of the test item at 25 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) 0.99.
Reference
Description of key information
A test was conducted to determine the n-octanol/water partition coefficient of the test substance according to the OECD Guideline 107 and EU Method A.8. The shake flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition coefficent of the test item at 25 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) 0.99.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.99
- at the temperature of:
- 25 °C
Additional information
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