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EC number: 266-041-3
CAS number: 65997-06-0
In a primary dermal irritation study, three
male New Zealand white rabbits were dermally exposed on intact skin to
0.5 gram of Gum Rosin for 4 hours under semi-occlusive contact. Animals
were then observed for a period of 72 hours post-treatment. Irritation
was scored by the method described in OECD Guideline 404. Except for
slight erythema noted at the application site of a single rabbit one
hour after termination of exposure, no signs of skin irritation
(erythema and/or edema) were evident during 24-, 48-, or 72-hour
examinations. Based on mean values of 0 for both erythema and edema at
the 24-, 48-, and 72-hour observations, Gum Rosin was not considered to
be a skin irritant to rabbits, and presents a low irritation hazard upon
skin contact under conditions of normal use.
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