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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Sodium ethyl xanthate: Acute Oral, Eye and Dermal Toxicity Report
Author:
Hazleton Laboratories
Year:
1951
Bibliographic source:
Acute Oral, Eye and Dermal Toxicity Report”, Virginia, USA, 1951.
Reference Type:
review article or handbook
Title:
Oral toxicity of xanthates
Author:
Kirk-Othmer Encyclopaedia of Chemical Technology
Year:
1984
Bibliographic source:
Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.
Reference Type:
review article or handbook
Title:
Priority existing chemical Report No. 5
Author:
Dep. of Health and Ageing, Australian Government
Year:
1995
Bibliographic source:
National Industrial Chemicals Notification and Assessment Scheme

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
The study was carried out in 1951 and complies generally with current test protocols such as the Organisation for Economic Cooperation and Development (OECD) guidelines for testing of chemicals No. 401. This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment. A 10% aqueous solution of sodium ethyl xanthate was administered orally by gavage. The pH of the solution was approximately 10.5 to 11. The animals were observed for signs of gross toxicological effects for seven days.
GLP compliance:
no
Test type:
other: LD50
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: compact
Details on test material:
- Name of test material (as cited in study report):Sodium Ethyl Xanthate
10% aqueous solution of sodium ethyl xanthate
Sodium O-ethyl dithiocarbonate (SEX) as the main constituent of Reaction mass of ethanol and sodium O-ethyl dithiocarbonate and sodium hydroxide

Test animals

Species:
mouse
Strain:
other: albino mice
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
500,600,750,900,1000,1500,2000,5000 mg
No. of animals per sex per dose:
93 male
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days


Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
730 mg/kg bw
Based on:
test mat.
Mortality:
The majority of deaths occurred on the first day and the animals that survived appeared normal within two days. The study does not indicate how many animals developed the symptoms, at what doses and the day of development of the symptoms.
Clinical signs:
Depression followed by hyperexcitability, tremors, paralysis, exophthalmia and clonic
followed by tonic convulsions. Pinkness of feet and nose, preening and salivation.
Body weight:
Weight gain amongst survivors was within normal limits.
Gross pathology:
Consolidated lungs, pale granular livers, unusually small spleens and atonic
intestines. Surviving animals showed no abnormalities.

Applicant's summary and conclusion

Interpretation of results:
other: sligthly toxic
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of 730 mg/kg was determined in a reliable study. This show that 10% aqueous solution of sodium ethyl xanthate as the main constituent of Reaction mass of ethanol and sodium O-ethyl dithiocarbonate and sodium hydroxide is of a Slightly order of acute oral toxicity .
Based on the data provided in this review, Reaction mass of SEX shall be classified for acute oral toxicity.
Executive summary:

The results of this study indicate that a 10% aqueous solution of sodium ethyl xanthate as the main constituent of Reaction mass of ethanol and sodium O-ethyl dithiocarbonate and sodium hydroxide has an oral LD50 of 730 mg/kg in male mice. The target organs for oral toxicity of sodium ethyl xanthate as the main constituent of Reaction mass of ethanol and sodium O-ethyl dithiocarbonate and sodium hydroxide were the central nervous system, liver and spleen.