Registration Dossier
Registration Dossier
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EC number: 500-078-0 | CAS number: 31923-84-9 1 - 4.5 moles propoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen, Düsseldorf, Germany
- Test type:
- other: acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethane- 1,2-diol, propoxylated
- EC Number:
- 500-078-0
- EC Name:
- Ethane- 1,2-diol, propoxylated
- Cas Number:
- 31923-84-9
- Molecular formula:
- HO(C3H6O)nC2H4(C3H6)nOH sum of n: >1 - <4.5 mol PO
- IUPAC Name:
- Ethane-1,2-diol, propoxylated
- Details on test material:
- - Physical state: liquid
- Content: 100%
- molecular weight: approx. 235
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- none: limit test
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no noticable gross pathological findings
Any other information on results incl. tables
Dose-response summary
Sex Dose mg/kg bw/day Toxicological result* Occurrence of signs Time of death Mortality [%]
males 2000 0 / 0 / 5 -- -- 0
females 2000 0 / 0 / 5 -- -- 0
*: number of animals which died spontaneously and/or were sacrificed in moribund state / number of animals with signs of toxicity / total number of animals used per group
Additional detailed tables are attached below under 'Attached background material'.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute dermal toxicity is low with a LD50 value exceeding 2000 mg/kg bw in rats.
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