(10R)-10-hydroxyoctadecanoic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Study Initiation Date: 23 Jun 2016 Study Completion Date: 21 Nov 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted 1995

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss Federal Office of Public Health, Bern, Switzerland

Type of method:

column elution method

Key result

Water solubility:

0.055 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

200 mg/L

Incubation duration:

ca. 7 - ca. 12 h

Temp.:

20 °C

pH:

> 7.67 - < 7.8

Details on results:

RESULTS AND DISCUSSION
The determination of the water solubility of 10-HSA was performed according to the OECD Guideline for the Testing of Chemicals, No. 105: Water Solubility, using the column elution method. The water solubility at 20°C was found to be 0.055 ± 0.008 mg/L.

The results of the measurements are given in Table 1.

According to the test guideline five consecutive samples should not differ in concentration by more than 30 % and the mean values obtained from two tests with different flows should not differ by more than 30 %. These criteria were fulfilled and therefore, the study is valid.

The R² fits of the calibration curves used were 0.9924 and 0.9943. This reflects the linearity of the analytical system within the calibration range of 0.0359 – 0.115 mg test item /L.

Table 1     Results for Determination of Water Solubility

 

Experiment Number	Flow Rate	pH	Measured Concentration	Mean ± Std. Dev.	Relative Standard Deviation
	[mL/min]		[mg/L]	[mg/L]	[%]
1	0.69	7.80	0.0601
		7.76	0.0513
		7.67	0.0524	0.051 ± 0.006	12
		7.67	0.0483
		7.71	0.0434
2	0.35	7.75	0.0517
		7.69	0.0718
		7.74	0.0523	0.060 ± 0.008	14
		7.71	0.0638
		7.69	0.0580
			Overall Mean:	0.055 ± 0.008	-

Conclusions:

In this study the water solubility of the test item 10-HSA was determined using the column elution method. The value was found to be 0.055 ± 0.008 mg/L at 20°C.

Executive summary:

This study was conducted to determine the water solubility of 10 HSA according to OECD Guideline 105.

Based on the estimated value (0.3315 mg/L) by QSAR calculation (EPI suite, WSKOW 1.41), the column elution method was used.

Under the conditions of the study , the water solubility of the test material was 0.055 ± 0.008 mg/L.

Description of key information

Water solubility is 0.055 mg/L (20 C), using column elution method (OECD 105).

Key value for chemical safety assessment

Water solubility:

0.055 mg/L

at the temperature of:

20 °C