Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
other: Not applicable since exclusively summarizing data coming from an existing risk assessment (BUA Report) are presented as executive summary.

Data source

Reference
Reference Type:
other: Risk assessment
Title:
Phenylenediamines, BUA Report 97
Author:
GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Year:
1992
Bibliographic source:
edited by the GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, Birkenwaldstraße 44, 70191 Stuttgart, 1995

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

p-phenylenediamine is absorbed following ingestion and is metabolized and rapidly excreted predominantly in acetylated form in the urin. There is no selective accumulation in target organs. p-phenylenediamine was found to bind to protein in the liver but not to DNA.