Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
A skin sensitization study performed according to Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406) found no indication of skin sensitization in guinea pigs for C9-14 aliphatics (2-25% aromatics). C9-14 aliphatics (2-25% aromatics) are not skin sensitizers in humans. C9-14 aliphatics (2-25% aromatics) were evaluated for its ability to induce skin sensitization in a 100+ person Human Repeated Insult Patch Test (HRIPT).

Migrated from Short description of key information:
C9-14 aliphatics (2-25% aromatics) were not dermal sensitizers using a Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406). C9-14 aliphatics (2-25% aromatics) were not dermal sensitizers in a Human Repeated Insult Patch Test (HRIPT).

Respiratory sensitisation

Endpoint conclusion
Additional information:

There are no reports of respiratory sensitization from C9-14 aliphatics (2-25% aromatics) in laboratory animals or humans.  However, a skin sensitization study utilizing C9-14 aliphatics (2-25% aromatics) found no indication of skin sensitization in guinea pigs.  Additional studies in humans also found no indication of skin sensitization.  With these observations, it is presumed that C9-14 aliphatics (2-25% aromatics) will not be a respiratory sensitizing agent.


Migrated from Short description of key information:
no data

Justification for classification or non-classification

These findings do not warrant the classification of C9-14 aliphatics (2-25% aromatics) hydrocarbon solvents as a skin or respiratory sensitizer under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.