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EC number: 700-488-1
CAS number: 873888-84-7
The in vitro study was performed to assess the eye irritation potential
of GR-86 -3792 by means of the Human Cornea Model Test.
Tissues of the human cornea model EpiOcular were treated with the test
item for 3, 30 and 60 minutes in duplicate. The cells for the negative
control were treated for 60min and the positive control were treated for
60min and the positive control for 15 and 45min each in duplicate.
100microL of the liquid test item were applied to each tissue, spread to
match the tissue size.
100microL of either the negative control (deionised water) or the
positive control (0.3% Triton X-100) were applied to each tissue.
After treatment with the negative control the absorbance values were
well above the required acceptability criterion of mean OD>=0.8 for the
60 min treatment interval thus showing the quality of the tissues.
Treatment with the positive control induced a sufficient decrease in the
relative absorbance after both treatment intervals as compared to the
negative control thus ensuring validity of the test system. No
irritating effects were observed following incubation with GR-86 -3792
up to the longest treatment period (60 min). Due to the lack of
cytotoxicity, a ET50 value could not be calculated.
In conclusion, it can be stated that in this study and under the
experimental conditions reported, the test item GR-86 -3792 does not
possess any eye irritating potential.
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