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EC number: 253-452-8
CAS number: 37294-49-8
A multi-generation study was performed similar to OECD 414 and 416. Male
and female rats (20/sex) were exposed to A-268 via feed at 0%, 1% or 4%
from weaning until reproductive age. Rats were mated several times:
first litter was sacrificed at weaning, the second litter was allowed to
mature and the rats were sacrificed at day 13 (10/20) or day 20 (10/20)
of the third pregnancy. The first litter of the F1 generation was
sacrificed at weaning, F1 rats were sacrificed at day 13 and 20 of the
second pregnancy (10 rats/ timepoint). No substance-related mortality
occurred in the parental animals of P and F1 generation, no
substance-related histopathology was found. The fertility index was
decreased for the highest concentration group calculated for both
litters of the P generation, but not for the first litter of the second
generation. The number of viable fetuses (average/ litter) was decreased
in a dose-related manner for all litters at both concentrations. This
corresponds to a dose-related decrease in the number of implantation
sites in both exposed groups seen in rats sacrificed at day 13 of
pregnancy. No substance-related anomalies were found in skeletal or soft
tissue of foetuses at day 20 of pregnancy. The viability of the pups
until weaning was decreased in the first litters of the P and F1
generation at the highest dose only. The average weaning weight of pups
was decreased (at least with 10%) at both dose levels in all litters.
Based on these results, an LOAEL for development of 1% A-268 was
established (corresponding to a dose level of appr. 500 mg solids/kg bw/
day) in absence of systemic toxicity of the parents.
Based on these results, an LOAEL for reproduction and development of 1%
A-268 was established (corresponding to a dose level of appr. 500 mg/kg
bw/ day) in absence of systemic toxicity of the parents. Based on the
available data, the LOAEL of disodium 4-isodecyl sulfosuccinate is
estimated to be 475 mg/ kg bw/ day.
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