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EC number: 253-452-8
CAS number: 37294-49-8
The individual in vitro irritancy scores for the negative controls
ranged from -0.4 to 0.7. The individual positive control in vitro
irritancy scores ranged from 156 to 168 for benzalkonium chloride (mean
IVIS = 161.6). The corneas treated with the positive control substance
were turbid after the 10 minutes of treatment.
A bovine corneal opacity and permeability (BCOP) test was performed with
disodium isodecyl sulfosuccinate according to OECD guideline and GLP
principles. Reliable positive and negative controls were included. The
corneas treated with disodium isodecyl sulfosuccinate were turbid with
spots after the 10 minutes of treatment. Mean in vitro irritancy score
was 38.1 after 10 minutes of treatment. The opacity value was 10 in all
three corneas treated with disodium isodecyl sulfosuccinate and
permeability values ranged from 0.406 to 2.785. based on an IVIS > 3 and ≤
55, no conclusion on classification for eye irritancy can be drawn
according to GHS UN.
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