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EC number: 253-452-8
CAS number: 37294-49-8
Table 1. 24 hour excretion of
2-ethylhexanol-forming compounds by the rat after oral dosage with DSS
% of dose excreted
-: not determined
The absorption, excretion and metabolism of dioctyl
sodium succinate (DSS) have been investigated. Unlabeled DSS and
radiolabeled compound (carbon-14) were used. Using a gas chromatographic
procedure, a similarity in percent excretion of dose into urine was
observed in rats dosed orally and intravenously, indicating a high
degree of absorption of the oral dose. Confirmation of extensive
absorption of DSS was obtained through oral dosage of 10 mg/kg carbon-14
labeled compound. Two thirds of the administered radioactivity was found
in the urine at 24 hours after dosage. All of the activity was in the
form of metabolites (2-ethylhexanol forming compounds).
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