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EC number: 221-117-5
CAS number: 3007-53-2
This study was performed to investigate
the potential of SAT 990560 (N,N-Dimethyldecan-1 -amide) to induce gene
mutations according to the plate incorporation test (experiment I) and
the pre-incubation test (experiment II) using the Salmonella typhimurium
The assay was performed with and without
liver microsomal activation. Due to technical reasons the results of
experiment II had to be dismissed and an additional experiment was
performed under identical conditions. The results of this additional
experiment are included in this report as experiment II. Each
concentration, including the controls, was tested in triplicate. The
test item was tested at the following concentrations:
3; 10; 33; 100; 333; and 1000 ug/plate
33; 66; 100; 333; 666; and 1000 ug/plate Experiment II (all strains):
33; 66; 100; 333; 666; and 1000 ug/plate
Toxic effects, evident as a reduction in
the number of revertants, occurred at the following concentrations:
Experiment II (µg/plate)
with S9 mix
333 - 1000
666 - 1000
/ no relevant toxic effects observed
In experiment I, the background growth
was reduced at the higher concentrations with and without S9 mix in all
No substantial increase in revertant
colony numbers of any of the five tester strains was observed following
treatment with SAT 990560 (N,N-Dimethyldecan-1 -amide) at any dose
level, neither in the presence nor absence of metabolic activation (S9
mix). There was also no tendency of higher mutation rates with
increasing concentrations in the range below the generally acknowledged
border of biological relevance.
Appropriate reference mutagens were used
as positive controls and showed a distinct increase of induced
In conclusion, it can be stated that
during the described mutagenicity test and under the experimental
conditions reported, the test item did not induce gene mutations by base
pair changes or frameshifts in the genome of the strains used.
Therefore, SAT 990560
(N,N-Dimethyldecan-1 -amide) is considered to be non-mutagenic in this
Salmonella typhimurium reverse mutation assay.
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